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US 2011/0217324 A1Published application
Inhibitors of antigen presentation by mhc class ii molecules and methods of use thereof
OwnerGary L. Olson, Christopher R. Self +2inventors
InventorsGary L. Olson, Christopher R. Self, Charles M. Cook, janet Cicariello Cook
Life of this patent
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Abstract
Provided herein are novel compounds, pharmaceutical compositions containing such compounds and methods for their use. In particular, the compounds described herein are useful for the treatment or prevention of diseases associated with T cell proliferation such as autoimmune diseases and disorders.
Claims13
A compound, or a pharmaceutically acceptable salt thereof, wherein the compound is:
- AcV(Chg)R(Tic)-(3′-Carbazolyl Ala);
- Ac(Cpg)R(Tic)F(homo Pro)COOH;
- Ac(Chg)R(Tic)-(4′-Indolyl Ala);
- Ac(Chg)R(Tic)-(3′-BnThienyl Ala);
- AcV(Chg)R(Tic)-(3′-BTA);
- Ac(Chg)R(Tic)F(2-azetidine);
- Ac(Cpg)(diMeK)(Tic)F(homo Pro);
- Ac(Cpg)R(Tic)F(2-azetidine);
- AcV(Chg)R(Tic)-(4′-Indolyl Ala);
- Ac(Chg)R(homo Pro)F(homo Pro);
- Ac(Chg)R(Tic)(Trp);
- Ac(Chg)R(Tic)(1-Me-Trp);
- Ac(Chg)(4-Gaun-Phe)(Tic)F(homo Pro);
- Ac(Chg)(homo R)(Tic)F(homo Pro);
- Ac(Chg)R(Tiq)F(homo Pro);
- Ac(Chg)R(Disc)F(homo Pro);
- Ac(Chg)(nor-R)(Tic)F(homo Pro);
- Ac(Thr)(Chg)R(Tic)F;
- AcV(Chg)A(Tic)F;
- AcV(Chg)(nor-Arg)(Tic)F;
- AcV(Cpg)R(Tic)F;
- AcV(Chg)R(Tic)(4′-F Phe);
- AcV(Chg)R(Tic)(Trp);
- AcV(Chg)H(Tic)F;
- AcV(Chg)R(homo Pro)F;
- AcV(Chg)R(Oic)F;
- Ac(t-BuG)(Chg)R(Tic)F;
- Ac(nor-V)(Chg)R(Tic)F;
- Ac(T(OMe))(Chg)R(Tic)F;
- AcV(Chg)R(Tic)(3,4-dichloro Phe);
- AcV(Indgly)R(Tic)F;
- AcV(Chg)(Cit)(Tic)F;
- AcV(Chg)R(Tic)(4-benzimidazole);
- AcV(Chg)R(Tic)F—COOH;
- AcV(Indgly)R(Tic)F—COOH;
- AcV(Chg)R(Tic)F—CONHMe;
- AcV(Indgly)R(Tic)F—CO(morpholine);
- AcV(Indgly)R(Tic)F—CONHMe;
- AcV(Chg)R(Tic)F—CO(morpholine);
- (NH2-Gly)V(Chg)R(Tic)F;
- (NH2-BTA)V(Chg)R(Tic)F;
- (NH2-Abu)V(Chg)R(Tic)F;
- (NH2-Sar)V(Chg)R(Tic)F;
- (NH2-Beta Ala)V(Chg)R(Tic)F;
- AcV(Chg)(homo Cit)(Tic)F;
- AcV(Chg)(nor Cit)(Tic)F;
- (NH2-Gly)V(Chg)(Cit)(Tic)F;
- (NH2-Sar)V(Chg)(Cit)(Tic)F;
- (NH2-Abu)V(Chg)(Cit)(Tic)F;
- (NH2-Beta Ala) V(Chg)(Cit)(Tic)F;
- AcV(Chg)R(Tic)(4-Indazole);
- AcV(Chg)R(Tic)(phenethylamide);
- AcV(Chg)R(Tic)(5-ethylamino indole);
- AcV(Chg)R(Tic)(2-ethylamino indole);
- AcV(Chg)R(Tic)(4-ethylamino indole);
- (NH2-Beta Ala)V(Chg)FFF;
- AcV(Chg)(GuanPipG)(Tic)F;
- (NH2-Beta Ala) V(Chg)(pyrimidinyl)(Tic)F;
- (NH2-Beta Ala)V(Chg)(4-thiaz Ala)(Tic)F;
- or
- AcV(Chg)(2-amino H is)(Tic)F.
58 more elements
Dependencies are inferred from the claim text.