GBS Toxin Receptor Compositions and Methods of Use
AssigneeVanderbilt University
InventorsCarl G. Hellerqvist, Changlin Fu
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Abstract
Methods are provided for preventing or attenuating pathoangiogenic conditions by administering at least one GBS toxin receptor polypeptide or at least one immunogenic fragment thereof. Also provided are a composition that includes a GBS toxin receptor polypeptide and a method for making such a composition. In another embodiment of the invention, immunized animals also receive GBS toxin, immunocompatible antibodies to the GBS toxin receptor, and/or expanded autologous T cells to the GBS toxin receptor. Also included in this invention are methods of identifying additional GBS toxin receptors.
Claims27
1-58. (canceled)
A polypeptide comprising a mammalian GBS toxin receptor or a fragment thereof.
A composition comprising an in inhibitor of binding of a GBS toxin to a mammalian GBS toxin receptor.
A method for inhibiting pathologic or hypoxia-driven endothelial cell proliferation or migration in a mammalian tissue, comprising specifically binding a molecule to a GBS toxin receptor present on the surface of at least one cell in the tissue, the molecule being selected from the group consisting of a compound that can evoke an inflammatory response when bound to a GBS toxin receptor in a mammal, a chimeric compound comprising a cytotoxic compound coupled to a compound that, specifically binds the GBS toxin receptor, an inhibitor of GBS toxin receptor phosphorylation and an inhibitor of GBS toxin receptor activity.
Dependencies are inferred from the claim text.