Treatment of orthopedic conditions
OwnerDavid L. Becker, Colin R. Green +1inventors
InventorsDavid L. Becker, Colin R. Green, Bradford James Duft
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Abstract
Methods, compounds, compositions, kits and articles of manufacture comprising anti-connexin agents for treatment of orthopedic disorder, disease, or condition, and promoting post-surgical wound-healing.
Claims66
A method of treating a subject undergoing an orthopedic procedure comprising administration of a composition comprising an anti-connexin 43 agent to a site of injury within said subject before, at the time of, or after said orthopedic procedure, wherein a surgical outcome is improved.
The method of claim 11, wherein the anti-connexin 43 agent is an antibody, F(v) fragment, Fab fragment, Fab′ fragment, or F(ab′)2 fragment.
A method of decreasing pain in a post-orthopedic-surgical subject comprising administration of a composition comprising an anti-connexin 43 agent during or at the conclusion of said surgery.
The method of claim 30 wherein the peptide is a peptidomimetic.
The method of claim 32, wherein the anti-connexin 43 agent is an antibody, F(v) fragment, Fab fragment, Fab′ fragment or F(ab′)2 fragment.
A method of treating and/or preventing, in whole or in part, post-orthopedic-surgical joint contracture in a subject by administering a composition comprising an anti-connexin 43 agent to said subject during or after said orthopedic surgery.
The method of claim 66 wherein the anti-connexin 43 agent is a peptide compound.
The method of claim 73 wherein the peptide compound is a peptidomimetic.
A method of treating a subject having or suspected of having or predisposed to, or at risk for an orthopedic disease, disorder, or condition characterized in whole or in part by abnormal tissue formation inside and/or around a joint, comprising administering a composition comprising an effective amount of an anti-connexin 43 agent.
Dependencies are inferred from the claim text.