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AssigneesThe Government of the United States of America as represented by the Secretary of the, The Department of Health and Human Services National Institutes of Health
InventorsMichael Otto, Stanislava Kocianova, Cuong Vuong, Jovanka Voyich, Yufeng Yao, Elizabeth Fischer, Frank De Leo
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Immunogenic compositions and methods for eliciting an immune response against S. epidermidis and other related staphylococci are provided. The immunogenic compositions can include immunogenic conjugates of poly-γ-glutamic acid (such as γDLPGA) polypeptides of S. epidermidis, or related staphylococci that express a γPGA polypeptide. The γPGA conjugates elicit an effective immune response against S. epidermidis, or other staphylococci, in subjects to which the conjugates are administered. A method of treating an infection caused by a Staphylococcus organism that expresses cap genes is also disclosed. The method can include selecting a subject who is at risk of or has been diagnosed with the infection by the Staphylococcus organism which expresses γPGA from the cap genes. Further, the expression of a γPGA polypeptide by the organism can then be altered.
A method of treating an infection caused by a Staphylococcus organism that secretes poly-γ-glutamic acid (γPGA), comprising:
A method of treating an S. epidermidis infection in a subject, comprising:
A method of detecting an organism from a Staphylococcus epidermidis group in a subject, comprising:
A method of producing poly-γ-glutamic acid (γPGA), comprising:
Dependencies are inferred from the claim text.