Novel Toxin-Antitoxin System
AssigneeUniversity of Medicine and Dentistry of New Jersey
InventorsMasayori Inouye, Yoshihiro Yamaguchi
Life of this patent
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Abstract
Disclosed in certain embodiments is a method of inhibiting cell function comprising inducing the expression of a mRNA interferase that cleaves mRNA at GCU.
Claims12
1-54. (canceled)
A method of treating a patient with a disease requiring the inhibition of cell function comprising administering to the patient a mRNA interferase that cleaves mRNA at GCx, wherein x is A, C, G, or U, or a gene encoding said mRNA interferase.
A method of cleaving mRNA comprising contacting an mRNA interferase that cleaves mRNA at GCx, wherein x is A, C, G, or U with mRNA.
A method of producing a polypeptide having endoribonuclease activity comprising:
- a. transforming a cell by introducing a polynucleotide encoding MqsR into the cell, and
- b. culturing the transformed cell.
A method of producing a polypeptide having antitoxin activity comprising:
- a. transforming a cell by introducing a polynucleotide encoding YgiT into the cell, and
- b. culturing the transformed cell,
Dependencies are inferred from the claim text.