Methods and compositions for delivery of exogenous factors to nervious system sites
AssigneesRegenerative Research Foundation, Albany Medical College
InventorsSally Temple, Natalia Lowry, Jeffrey Stern, Susan K. Goderie
Life of this patent
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Abstract
The present invention relates to treatment methods and methods for sustained delivery of one or more exogenous factors to desired nervous system sites. In certain embodiments, the invention relates to the use of biodegradable microspheres to deliver exogenous factors, such as the morphogenic factor, sonic hedgehog (Shh), to the site of spinal cord injury. In certain embodiments, the Shh-releasing microspheres are administered together with stem cells, which may be spinal cord neural stem cells. In certain embodiments, the invention relates to regrowth of neural cells in both the central and peripheral nervous systems.
Claims25
A method for treating a nervous system injury in a mammal comprising administering to a mammal at a site of nervous system injury an effective amount for treating the nervous system injury of a pharmaceutical formulation comprising at least one exogenous growth factor, said pharmaceutical formulation providing sustained delivery of the at least one exogenous growth factor for at least about 7 days.
(canceled)
A method for increasing neural cell growth or regenerating neural cells in a mammal which comprises administering, to a mammal at a site at which it is desired to increase neural cell growth or regenerate neural cells, an effective amount for increasing neural cell growth or regenerating neuronal cells of a sustained release pharmaceutical formulation comprising at least one exogenous growth factor, said pharmaceutical formulation continuously delivering the at least one exogenous growth factor for at least about 7 days.
(canceled)
25-32. (canceled)
Dependencies are inferred from the claim text.