Treatment of Ocular Surface Disorders by Increasing Conjunctival Vascular Permeability
OwnerJulia A. Kornfield, Robert H. Grubbs +4inventors
InventorsJulia A. Kornfield, Robert H. Grubbs, Choon Woo Lee, Daniel Schwartz, Phoebe Lin, Keith Duncan
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Abstract
A method of treating an ocular surface disorder in a subject in need of such treatment is provided. The method includes exposing conjunctival tissue of the subject to an effective amount of a vasopermeability agent that increases conjunctival vascular permeability. In some embodiments, the agent is a nitric oxide donor, which may be in a sustained release form. A method of screening a substance for treating an ocular surface disorder is also provided.
Claims14
A method of treating an ocular surface disorder in a subject in need of such treatment, comprising increasing vascular permeability of conjunctival blood vessels of the subject.
A method of screening a substance for treating an ocular surface disorder, comprising exposing conjunctival tissue to a substance, and determining if exposure to the substance increases conjunctival vascular permeability with minimal or no inflammation.
A nitric oxide donor of the following formula:
Dependencies are inferred from the claim text.