Conjugates of 19f mr imaging tracers for use in multi-chromic mri imaging
AssigneeUniversity of Maryland, Baltimore
InventorsYihua Bruce Yu, Zhong-Xing Jiang
Life of this patent
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Abstract
Compositions for producing multi-chromic (“color”) magnetic resonance images (MRI). The compositions for use as MRI imaging agents include a magnetic resonance imaging tracer having a signal emitter, such as a 19F imaging tracer (19FIT), conjugated with a magnetic signal modulator, such as a paramagnetic functional group or a paramagnetic ion. The 19FIT and the signal modulator (M) are joined covalently by a chelator such as DOTA, forming a nanometer-sized fluorinated paramagnetic complex 19FIT-DOTA-M. Other signal emitters, such as 31P imaging tracer (31PIT), can also be modulated using this strategy (i.e., 31PIT-DOTA-M) to generate multi-chromic 31P MRI or MRS.
Claims20
A composition comprising a magnetic resonance (MR) imaging tracer conjugated with at least one of a paramagnetic functional group or a chelate complex of a ligand combined with a paramagnetic ion or a diamagnetic ion.
A method of removing and identifying heavy metals or radioactive materials from a contaminated area or entity, the method comprising administering a magnetic resonance (MR) imaging tracer conjugated with a chelate complex of a ligand combined with a calcium ion or a magnesium ion to the contaminated area or entity, wherein the calcium ion or magnesium ion is replaced by metal ions from the contaminated area or entity.
Dependencies are inferred from the claim text.