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US 2011/0217240 A1Published application
Imaging neuroleptic compounds
OwnerCraig Ferrisinventor
Life of this patent
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Abstract
A method for identifying typical and atypical antipsychotics based on their ability to reduce neuronal/glial activity in specific brain regions upon dopaminergic neurotransmission is disclosed.
Claims17
A method for identifying a typical antipsychotic drug, comprising:
- a. pre-treating a conscious subject with an effective amount of a test neuroleptic;
- b. measuring neuronal/glial activity in the hippocampus of the subject by functional imaging;
- c. administering a drug that activates dopaminergic neurotransmission to the subject sufficient to alter measurable subject behavior;
- d. measuring neuronal/glial activity in the hippocampus of the subject after administration of the drug that activates dopaminergic neurotransmission;
- and
- e. comparing the neuronal/glial activity in the hippocampus of the subject prior to and subsequent to the administration of the drug that activates dopaminergic neurotransmission,
- a decrease in neuronal/glial activity in the hippocampus indicating that the test neuroleptic is a typical antipsychotic drug.
4 more elements
A method for identifying an antipsychotic drug, comprising:
- a. pre-treating a conscious subject with an effective amount of a test neuroleptic;
- b. measuring neuronal/glial activity in the pituitary gland of the subject by functional imaging;
- c. administering a drug that activates dopaminergic neurotransmission to the subject sufficient to alter measurable subject behavior;
- d. measuring neuronal/glial activity in the pituitary gland of the subject after administration of the drug that activates dopaminergic neurotransmission;
- and
- e. comparing the neuronal/glial activity in the pituitary gland of the subject prior to and subsequent to the administration of the drug that activates dopaminergic neurotransmission,
- a decrease in neuronal/glial activity in the pituitary gland indicating that the test neuroleptic is an antipsychotic drug.
4 more elements
A method for identifying an antipsychotic drug, comprising:
- a. pre-treating a conscious subject with an effective amount of a test neuroleptic;
- b. measuring neuronal/glial activity in the anterior thalamic nuclei of the subject by functional imaging;
- c. administering a drug that activates dopaminergic neurotransmission to the subject sufficient to alter measurable subject behavior;
- d. measuring neuronal/glial activity in the anterior thalamic nuclei of the subject after administration of the drug that activates dopaminergic neurotransmission;
- and
- e. comparing the neuronal/glial activity in the anterior thalamic nuclei of the subject prior to and subsequent to the administration of the drug that activates dopaminergic neurotransmission,
- a decrease in neuronal/glial activity in the anterior thalamic nuclei indicating that the test neuroleptic is an antipsychotic drug.
4 more elements
Dependencies are inferred from the claim text.