Method for Determination of the Responsiveness of an Individual to Misletoe Lectin
OwnerJohannes Muthing, Jasna Peter-Katalinic +3inventors
InventorsJohannes Muthing, Jasna Peter-Katalinic, Martin Langer, Babette Mockel, Jurgen Eck
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Abstract
A method for the determination of the responsiveness of an individual to mistletoe lectin or to (an) mistletoe lectin single chain(s), wherein the expression of a membrane-bound receptor for mistletoe lectin is characteristic of a corresponding responsiveness.
Claims19
1-9. (canceled)
An in vitro method for the determination of a responsiveness to mistletoe lectin(s), comprising quantitative and/or qualitative determination of at least one α2,6-sialyltransferase.
A diagnostic composition comprising a substance which specifically recognizes or binds to a receptor characterized by a terminal N-acetyl neuraminic acid (Neu5Ac) which is linked to a galactose (Gal) by a glycosidic α2-6 bond and is selected from the group consisting of antibodies, antibody derivatives, antibody fragments, aptamers, low-molecular substances and carbohydrate-binding peptides.
A method of treating a proliferative disease, viral disease, autoimmune disease or neuronal disease, comprising administering a pharmaceutical composition to an individual, wherein the pharmaceutical composition comprises a substance that specifically binds to a receptor or recognizes a membrane-bound receptor, wherein the receptor is characterized by a terminal N-acetyl neuraminic acid (Neu5Ac) which is linked to a galactose (Gal) by a glycosidic α2-6 bond and wherein the receptor-binding or receptor-recognizing substance is selected from the group consisting of antibodies, antibody derivatives, antibody fragments, aptamers, low-molecular substances and carbohydrate-binging peptides.
Dependencies are inferred from the claim text.