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US 2011/0214745 A1Published application
Microfluidic chips and assay systems
AssigneeRheonix, Inc.
InventorsPeng Zhou, Lincoln C. Young
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Abstract
The systems and methods described herein include a microfluidic chip having a plurality of microfeatures interconnected to provide a configurable fluid transport system for processing at least one reagent. Inserts are provided to removably interfit into one or more of the microfeatures of the chip, wherein the inserts include sites for interactions with the reagent. As will be seen from the following description, the microfluidic chip and the inserts provide an efficient and accurate approach for conducting parallel assays.
Claims11
A method for conducting a biological assay, comprising:
- providing microfluidic device, comprising:
- a substrate having a plurality of channels disposed therein, each of the channels having an inlet end and an outlet end;
- a plurality of reservoirs in fluid connection with the plurality of channels;
- at least one bi-directional diaphragm pump comprising at least three non-elastomeric membrane-based valve structures;
- a distribution valve disposed in fluid connection with at least two of the reservoirs and at least one of the channels;
- and
- at least one insert disposed within at least one of the channels;
- flowing at least one fluid material through the channel to contact the insert;
- drawing the fluid material away from the insert;
- and
- detecting an interaction on the insert.
8 more elements
Dependencies are inferred from the claim text.