Methods For Treating Clinical Conditions Associated With Lipoprotein Lipase Activity
AssigneeThe Regents of the University of Colorado, a body corporate
InventorsRobert H. Eckel, Hong Wang
Life of this patent
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Abstract
The present invention provides methods for treating a clinical condition associated with lipoprotein lipase activity in the brain of a subject.
Claims21
A method of treating or preventing a clinical condition associated with lipoprotein lipase activity in the brain of a subject, said method comprising administering to the subject a composition comprising a compound that modulates lipoprotein lipase activity in the brain of the subject.
A transgenic non-human mammal comprising neuronal specific LPL deficiency compared to the wild type of said non-human mammal.
A method for identifying a small molecule that is suitable for treating or preventing a clinical condition associated with decreased lipoprotein lipase activity in the brain of a subject, said method comprising:
- administering the small molecule to a non-human mammal comprising neuronal specific LPL deficiency compared to the wild type of said non-human mammal;
- and
- determining the level of neuronal specific LPL activity in the non-human mammal, wherein if the level of neuronal specific LPL activity in the non-human mammal is substantially similar to the level of neuronal specific LPL activity in the control, then it is indication that the small molecule is suitable for treating or preventing clinical condition associated with decreased lipoprotein lipase activity in the brain of a subject.
Dependencies are inferred from the claim text.