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AssigneesAllele Biotechnology & Pharmaceuticals, Inc., University of Alberta, TEC Edmonton
InventorsJiwu Wang, Robert Earl Campbell, Hiofan Hoi, Nathan Christopher Shaner
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The present disclosure provides an isolated nucleic acid sequence encoding a monomeric photoconvertible fluorescent protein, and fragments and derivatives thereof. Also provided is a method for engineering the nucleic acid sequence, a vector comprising the nucleic acid sequence, a host cell comprising the vector, and use of the vector in a method for expressing the nucleic acid sequence. The present disclosure further provides an isolated nucleic acid, or mimetic or complement thereof, that hybridizes under stringent conditions to the nucleic acid sequence. Additionally, the present provides a monomeric photoconvertible fluorescent protein encoded by the nucleic acid sequence, as well as derivatives, fragments, and homologues thereof. Also provided is an antibody that specifically binds to the photoconvertible fluorescent protein.
An isolated nucleic acid encoding the amino acid sequence of SEQ ID NO:
An isolated nucleic acid encoding a photoconvertible chromoprotein or fluorescent mutant thereof wherein said nucleic acid has a sequence identity of at least about 90% with SEQ ID NO:
An isolated nucleic acid encoding a chromo- or fluorescent protein, wherein said protein has a sequence identity of at least about 95% with SEQ ID NO:
A transgenic animal comprising a nucleic acid having a sequence identity of at least about 90% with SEQ ID NO:
A transgenic plant comprising a nucleic acid having a sequence identity of at least about 90% with SEQ ID NO:
Dependencies are inferred from the claim text.