System, method, and computer product for exon array analysis
AssigneeAffymetrix, Inc.
InventorsAlan J. Williams, Charles W. Sugnet, James H. Gorrell
Life of this patent
Estimating the term…
Abstract
In one embodiment, a method for analyzing data generated by probe arrays is described that comprises receiving user selections of two or more data files and an identification of one or more subsets of intensity values acquired from a biological probe array. The method includes iteratively opening each data file, identifying the selected subset of intensity values associated with each open data file, determining parameters for processing, storing the parameters and the identified intensity values, and closing the open data file prior to the subsequent iteration. The method then includes processing the stored intensity values using the parameters to identify one or more biological events.
Claims15
-29. (canceled)
A method for normalizing probe array intensity data, the method comprising:
- providing a computer with a computer program, wherein the program is designed to receive one or more data files, wherein each data file comprises a plurality of intensity values acquired from one or more probe arrays, and wherein the program is additionally designed to normalize intensity values stored in the data files;
- retrieving intensity values from one or more data files;
- normalizing retrieved intensity values, wherein the normalization is based upon a normalization subset of intensity values, wherein the normalization subset comprises one or more of the retrieved intensity values, and wherein the intensity values of the normalization subset are selected without analyzing every retrieved intensity value;
- and
- storing the normalized intensity values.
A system for normalizing probe array intensity data, the system comprising:
- a scanner, wherein the scanner is designed to acquire a plurality of pixel intensity values from a probe arrays;
- and
- a computer, the computer comprising:
- system memory;
- and
- a computer program, wherein the scanner and the computer program are designed to stored the acquired pixel intensity values within one or more data files, and wherein the computer program comprises executable code for implementing a method, the method comprising:
- retrieving intensity values from one or more data files;
- normalizing retrieved intensity values, wherein the normalization is based upon a normalization subset of intensity values, wherein the normalization subset comprises one or more retrieved intensity values, and wherein the intensity values of the normalization subset are selected without analyzing every retrieved intensity value;
- and
- storing the normalized intensity values within one or more data files in the system memory.
Dependencies are inferred from the claim text.