Injection of fibrin sealant in the absence of corticosteroids in spinal applications
OwnerSteven I. Whitlock, Brian D. Burkinshaw +3inventors
InventorsSteven I. Whitlock, Brian D. Burkinshaw, Kevin Pauza, John L. Wheeler, Kevin Thorne
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Abstract
A method and kit for treating a disc that is leaking nucleus pulposus through at least one defect in the annulus fibrosus. The method includes injecting a fibrin sealant into the disc to reduce at least a portion of the at least one defect, wherein the fibrin sealant injected into the disc comprises fibrinogen and an activating compound, wherein at least a portion of the fibrin forms after injection, with the proviso that a corticosteroid is absent from the fibrin sealant injected into the disc.
Claims18
A composition for forming a resorbable tissue scaffold for enhancing tissue repair of at least one fissure in the anulus fibrosus of a painful intervertebral disc comprising:
- fibrinogen, thrombin, and calcium chloride.
A method of enhancing tissue repair of at least one defect in the anulus fibrosus of an intervertebral disc comprising:
- injecting fibrinogen, thrombin, calcium chloride, and aprotinin into a disc;
- wherein (a) the fibrinogen and thrombin react to form a fibrin clot within at least a portion of at least one defect in the anulus fibrosus, (b) the fibrin clot includes a resorbable scaffold for tissue formation, and (c) the aprotinin downregulates the cellular synthesis of inflammatory cytokines and upregulates the syntheses of tissue growth factors to promote tissue repair.
A method of enhancing tissue repair of at least one defect in the anulus fibrosus of an intervertebral disc comprising:
- injecting fibrinogen, thrombin, calcium chloride, and a fibrinolysis inhibitor into a disc;
- wherein (a) the fibrinogen and thrombin react to form a fibrin clot within at least a portion of at least one defect in the anulus fibrosus, (b) the fibrin clot includes a resorbable scaffold for tissue formation, (c) the fibrinolysis inhibitor downregulates the cellular synthesis of inflammatory cytokines and upregulates the syntheses of tissue growth factors to promote tissue repair.
Dependencies are inferred from the claim text.