Porous Synthetic Vascular Grafts with Oriented Ingrowth Channels
AssigneeMedtronic, Inc.
InventorsPeter Paul Zilla, Deon Bezuidenhout
Life of this patent
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Abstract
A vascular prosthesis is constructed from a structure having interconnected, helically oriented channel-porosity to allow oriented ingrowth of connective tissue into a wall of the prosthesis. The prosthesis can have a small internal diameter of 6 mm or less. Several different methods can be used to produce the prosthesis, including a fiber winding and extraction technique, a melt extrusion technique, and a particle and fiber extraction technique using either a layered method or a continuous method. Furthermore, mechanical properties of prosthesis are matched with mechanical properties of the host vessel, thereby overcoming problems of compliance mismatch.
Claims29
1-44. (canceled)
A method of making a prosthesis comprising the steps of:
- preparing a paste comprising a graft material solution and an extractable filler;
- depositing a layer of the paste onto a mandrel, wherein the mandrel has a diameter about equal to a desired inside diameter of the vascular graft prosthesis;
- winding an extractable fiber onto the layer of paste;
- successively depositing additional layers of the paste and winding the extractable fiber onto each layer of the paste until a desired thickness of the vascular graft prosthesis is achieved;
- precipitating graft material from the graft material solution;
- and
- extracting the fiber from the graft material.
A method of making a prosthesis comprising the steps of:
- preparing a paste comprising a graft material solution and an extractable filler;
- depositing a layer of the paste onto a mandrel, and simultaneously winding an extractable fiber onto the mandrel, until a desired thickness of the vascular graft prosthesis is achieved, wherein the mandrel has a diameter about equal to a desired inside diameter of the vascular graft prosthesis;
- precipitating graft material from the graft material solution;
- and
- extracting the fiber from the graft material.
Dependencies are inferred from the claim text.