Transdermal methods and systems for the delivery of anti-migraine compounds

An integrated iontophoretic transdermal patch for the delivery of a triptan compound or a salt thereof, the patch comprising:

• a triptan compound disposed in a drug reservoir;
• a return reservoir;
• and
• an electronic circuit in electrical connection with the reservoirs, the electronic circuit comprising:
• a voltage source;
• an active electrode which does not significantly react to form an insoluble salt of the triptan compound;
• a return electrode;
• and
• a transistor,
• the electrical circuit operative to provide a delivery sequence which includes:
• a first stage delivery wherein current densities average between about 0.05 and about 0.20 mA/cm2 during a significant portion of the first stage delivery;
• and
• a second stage delivery wherein current densities average between about 0.01 and about 0.2 mA/cm2 during a significant portion of said second stage delivery.