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AssigneeNanobiotix
InventorsLaurent Levy, Agnes Pottier, Annabelle Rouet, Julie Marill, Corinne Devaux, Matthieu Germain
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The present application relates to novel excitable particles which can be used in the health sector. It more particularly relates to particles which can generate electrons and/or high energy photon when excited by ionizing radiations such as X- Rays, γ-Rays, radioactive isotope and/or electron beams, and to the uses thereof in health, in particular in human health. The inventive particles are made of an inorganic material comprising oxygen, in particular an oxide, said material having an adequate density, and can be activated in vitro, ex vivo, or in vivo, by controllable external excitation, in order to disturb, alter or destroy target cells, tissues or organs. The invention also relates to methods for the production of said particles, and to pharmaceutical or medical device compositions containing same.
1-15. (canceled)
A method for altering, destroying or eliminating target cells in an animal by i) administering a nanoparticle or nanoparticle aggregate or a composition comprising a nanoparticle or nanoparticle aggregate, wherein the nanoparticle is made of an oxide (MyOy), the density of the nanoparticle or nanoparticle aggregate is of at least 7 g/cm3, and the nanoparticle or nanoparticle aggregate is covered with a biocompatible coating allowing the nanoparticle stability between pH 6.5 and 7.5 in a physiological fluid, and ii) exposing said animal to ionizing radiations.
A pharmaceutical composition intended to alter or destroy target cells in a mammal when said cells are exposed to ionizing radiations, said pharmaceutical composition comprising a nanoparticle or nanoparticle aggregate and a pharmaceutically acceptable excipient, wherein the nanoparticle is made of an oxide (MxOy);), the density of the nanoparticle or nanoparticle aggregate is of at least 7 g/cm3, and the nanoparticle or nanoparticle aggregate is covered with a biocompatible coating allowing the nanoparticle stability between pH 6.5 and 7.5 in a physiological fluid.
Dependencies are inferred from the claim text.