Process for preparation of celecoxib crystalline form
OwnerVamsee Krishna Muppidi, Srinivasulu Rangineni +3inventors
InventorsVamsee Krishna Muppidi, Srinivasulu Rangineni, Naga Kiran Duggirala, Srividya Ramakrishnan, Arjun Kumar Tummala
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Abstract
Celecoxib crystalline Form Ill substantially free of celecoxib crystalline Forms I and II and a process for its preparation.
Claims11
A process for the preparation of crystalline Form III of celecoxib substantially free of polymorphic Forms I and II comprising:
- a) providing a solution of celecoxib in an alcoholic or a nitrile solvent;
- b) combining the solution of celecoxib with water;
- and
- c) isolating pure crystalline Form III of celecoxib.
A process for preparation of crystalline Form III of celecoxib substantially free of crystalline forms I and II comprising wet milling a sample of crystalline Form III of celecoxib.
Crystalline Form III of celecoxib substantially free from crystalline Forms I and II.
Dependencies are inferred from the claim text.