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US 2011/0213155 A1Published application
Optical purification of esomeprazole
AssigneeHetero Research Foundation
InventorsBandi Parthasaradhi Reddy, Kura Rathnakar Reddy, Rapolu Raji Reddy, Dasari Muralidhara Reddy
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Abstract
The present invention relates to process for optical purification of esomeprazole or a salt thereof. Thus, esomeprazole sodium having 20 to 1% R-omeprazole by weight of the sum of the contents of esomeprazole and R-omeprazole is precipitated from a solvent selected from an alcohol or a mixture of alcohols and the precipitated solid is collected to obtain optically pure esomeprazole sodium.
Claims5
A process for optical purification of esomeprazole or a salt thereof, which process comprises:
- a. preparing a solution of esomeprazole sodium having 20 to 1% R-omeprazole by weight of the sum of the contents of esomeprazole and R-omeprazole in a solvent selected from an alcohol or a mixture of alcohols;
- b. precipitating esomeprazole sodium;
- and
- c. collecting the precipitated substantially pure esomeprazole sodium.
1 more element
Dependencies are inferred from the claim text.