Antisense modulation of stearoyl-coa desaturase expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsSanjay Bhanot, Kenneth W. Dobie, John G. Geisler, Mark J. Graham
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of stearoyl-CoA desaturase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding stearoyl-CoA desaturase. Methods of using these compounds for modulation of stearoyl-CoA desaturase expression and for treatment of diseases associated with expression of stearoyl-CoA desaturase are provided.
Claims15
A compound 8 to 80 nucleobases in length targeted to a nucleic acid molecule encoding human stearoyl-CoA desaturase (SCD1), wherein the compound specifically hybridizes with a nucleic acid molecule encoding human stearoyl-CoA desaturase and inhibits the expression of human stearoyl-CoA desaturase by at least 50%.
Dependencies are inferred from the claim text.