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US 2011/0213135 A1Published application
Cytotoxic Nucleotides for Targeted Therapeutics
AssigneeWake Forest University Health Sciences
InventorWilliam H. Gmeiner
Life of this patent
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Abstract
The present invention provides a method of generating a nucleic acid, which specifically binds to an extracellular surface protein expressed by a cell of interest, and which nucleic acid comprises a compound of interest to be delivered to the cell of interest.
Claims21
-32. (canceled)
A nucleic acid molecule, comprising:
- (i) a nucleotide sequence that specifically binds to an extracellular surface protein expressed by a cell of interest;
- and
- (ii) a compound of interest;
- wherein the nucleic acid molecule ranges from about 30 nucleotides to about 150 nucleotides in length.
1 more element
A nucleic acid molecule, comprising:
- (i) a nucleotide sequence that specifically binds to an extracellular surface protein expressed by a cell of interest, wherein the nucleotide sequence comprises SEQ ID NO:1;
- and
- (ii) a cytotoxic nucleotide;
- wherein the nucleic acid molecule ranges from about 30 nucleotides to about 150 nucleotides in length.
1 more element
A nucleic acid molecule consisting of SEQ ID NO:1 and FdUMP[9]dC appended to the 3′-terminus of SEQ ID NO:1.
Dependencies are inferred from the claim text.