Synthetic membrane anchors
AssigneeKode Biotech Limited
InventorsNicolai Bovin, Lissa Gilliver, Stephen Henry, Elena Korchagina
Life of this patent
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Abstract
The invention relates to synthetic molecules that spontaneously and stably incorporate into lipid by-layers, including cell membranes. Particularly, although not exclusively, the invention relates to the use of these molecules as synthetic membrane anchors or synthetic molecule constructs to effect qualitative and quantitative changes in the expression of cell surface antigens.
Claims15
1-187. (canceled)
A synthetic molecule construct of the structure F-31-S2-L where:
- F is a mono-, di-, tri- or oligo-saccharide;
- S1 is 2-aminoethyl, 3-aminopropyl, 4-aminobutyl, or 5-aminopentyl;
- S2 is —CO(CH2)2CO—, —CO(CH2)3CO—, —CO(CH2)4CO— or —CO(CH2)5CO—;
- and
- L is a diacyl- or dialkyl-glycerophospholipid.
A synthetic molecule construct:
- designated Atri-sp-Ad-DOPE (I).
A synthetic molecule construct:
- designated Atri-sp-Ad-DS PE (III).
A synthetic molecule construct:
- designated Btri-sp-Ad-DOPE (VI).
A synthetic molecule construct:
- designated Htri-sp-Ad-DOPE (VII).
A synthetic molecule construct:
- designated Hdi-sp-Ad-DOPE (VIII).
A synthetic molecule construct:
- designated Galβ-sp-Ad-DOPE (IX).
A synthetic molecule construct:
- designated Fucα1-2Galβ1-3GlcNAcβ1-3Galβ1-4GlcNAc-sp-Ad-DOPE (XII).
A synthetic molecule construct:
- designated Fucα1-2Galβ1-3(Fucα1-4)GlcNAc-sp-Ad-DOPE (XIII).
Dependencies are inferred from the claim text.