Loading patent…
AssigneeThe University of Melbourne
InventorsEric Charles Reynolds, Peter Singh Bhogal, Nada Slakeski
Estimating the term…
This invention relates to the PrtR-PrtK cell surface protein of Porphyromonas gingivalis and in particular a multimeric cell association protein complex comprising the PrtR and PrtK proteins. Accordingly the invention provides a substantially purified antigenic complex for use in raising an antibody response directed against Porphyromonas gingivalis. The complex comprises at least one multimeric protein complex of arginine-specific and lysine-specific thiol endopeptidases each containing at least one adhesin domain, the complex having a molecular weight of greater than about 200 kDa. The invention also relates to pharmaceutical compositions and associated agents based on said complex for the detection, prevention and treatment of Periodontal disease associated with P. gingivalis.
1-20. (canceled)
An antibody preparation comprising antibodies specifically directed against a substantially purified antigenic complex from Porphyromonas gingivalis, the complex comprising at least one multimeric protein complex of arginine-specific and lysine-specific thiol endopeptidases each containing at least one adhesion domain, the complex having a molecular weight of about 294 to about 323 kDa wherein the multimeric protein complex comprises 9 proteins, the 9 proteins having the following N-terminal sequences:
Dependencies are inferred from the claim text.