Methods for using and identifying modulators of delta-like 4
AssigneeVasGene Therapeutics, Inc.
InventorsParkash Gill, Ren Liu, Valery Krasnoperov
Life of this patent
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Abstract
In certain embodiments, this present invention provides antibodies that act as either agonists or antagonists of Delta-like 4 (Dll4) signaling.
Claims19
An isolated monoclonal antibody or antigen-binding portion thereof that binds to Dll4, wherein the antibody or the antigen-binding portion thereof comprises heavy chain CDRs identical to the CDRs of a variable region VH set forth in SEQ ID NO:
- 4, and light chain CDRs identical to the CDRs of a variable region VL set forth in SEQ ID NO:
- 5.
An isolated monoclonal antibody or antigen-binding portion thereof that binds to Dll4, wherein the antibody or the antigen-binding portion thereof comprises heavy chain CDRs identical to the CDRs of a variable region VH set forth in SEQ ID NO:
- 6, and light chain CDRs identical to the CDRs of a variable region VL set forth in SEQ ID NO:
- 7.
An isolated monoclonal antibody or antigen-binding portion thereof that binds to Dll4, wherein all CDRs of the antibody or the antigen-binding portion thereof are present in the sequences set forth in SEQ ID NOs:
- 4 and 5.
An isolated monoclonal antibody or antigen-binding portion thereof that binds to Dll4, wherein all CDRs of the antibody or the antigen-binding portion thereof are present in the sequences set forth in SEQ ID NOs:
- 6 and 7.
An isolated monoclonal antibody or antigen-binding portion thereof that comprises at least one CDR of a reference antibody having a sequence selected from SEQ ID NOs:
- 4-7.
An isolated monoclonal antibody or antigen-binding portion thereof that binds to an epitope situated in the extracellular portion, wherein said epitope is situated within a domain selected from MNNL, DSL, and one or more EGF repeats.
An isolated monoclonal antibody or antigen-binding portion thereof that binds to Dll4 and inhibits Dll4-Notch interaction.
Dependencies are inferred from the claim text.