Compositions and methods for regulation of smooth muscle cells and blood pressure
AssigneeBoard of Trustees of the University of Arkansas
InventorsSung W. Rhee, Paul L. Hermonat, Nancy J. Rusch
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Abstract
The invention encompasses a composition for regulating smooth muscle cells. In particular, the invention encompasses a vector comprising a smooth muscle promoter operably-linked to a nucleic acid encoding a calcium-activated potassium channel.
Claims12
A method for regulating the blood pressure of a mouse, the method comprising administering to the mouse a vector comprising a smooth muscle specific promoter operably linked to a nucleic acid sequence encoding a calcium-activated potassium channel.
A method of expressing a calcium-activated potassium channel in a smooth muscle cell, the method comprising contacting the smooth muscle cell with a vector comprising a smooth muscle specific promoter operably-linked to a nucleic acid sequence encoding a calcium-activated potassium channel.
Dependencies are inferred from the claim text.