N-(2-thiazolyl)-amide derivatives for the treatment of obesity, diabetes and cardiovascular diseases

A method of treating and/or preventing a disease or disorder presenting altered adiponectin levels or in which it is necessary to alter the adiponectin levels, said method comprising administering a pharmaceutical composition comprising a therapeutically effective amount of at least one compound, pharmaceutically acceptable salt, prodrug and/or solvate of formula (I) to a patient who needs such treatment:

• wherein:
• R1 and R2 are independently selected from the group consisting of H, halogen, —NO2, —NH2, CN, a substituted aryl group, a non-substituted aryl group, a linear C1-C6 alkyl group, and (CH2)nCO2R8, wherein n is an integer selected from 1, 2 and 3, and R8 is H or a linear C1-C6 alkyl group;
• X is selected from:
• an indazole of formula (A), joined to position 3:
• and
• a pyridine of formula (B) joined to position 2:
• wherein
• R3 is selected from H and linear C1-C6 alkyl;
• R4, R5, R6 and R7 are independently selected from the group consisting of H, C1-C6 alkyl,
• C1-C6 alkoxy, and halogen.