Pyridine derivatives as s1p1/edg1 receptor modulators

A compound of Formula (I).

• Pyridine1-A-Pyridine2 Formula (I)
• wherein
• Pyridine1 represents
• wherein the asterisks mark the bond with which the Pyridine1 ring is bound to A;
• R1 represents C1-5-alkyl, C1-4-alkoxy, C3-6-cycloalkyl, hydroxymethyl, or NR1aR1b;
• R1a represents C1-4-alkyl;
• R1b represents hydrogen, or C1-3-alkyl;
• or R1a and R1b, together with the nitrogen that is attached to the pyridine, form a pyrrolidine ring;
• R2 represents hydrogen, or C1-4-alkyl, or in case R1 represents C1-5-alkyl or C3-6-cycloalkyl, R2 may in addition represent methoxy;
• R3 represents C1-5-alkyl, C1-4-alkoxy, C3-6-cycloalkyl, or NR3aR3b;
• R3a represents C1-4-alkyl;
• R3b represents hydrogen, or C1-3-alkyl;
• R4 represents C1-4-alkyl, or hydrogen;
• R5 represents C1-5-alkyl, methoxy, or NR5aR5b;
• and R6 represents C1-2-alkyl;
• R5a represents C1-4-alkyl;
• R5b represents hydrogen, or C1-3-alkyl;
• or
• R5 represents C1-2-alkyl, or methoxy;
• and R6 represents C1-5-alkyl, or NR6aR6b;
• R6a represents C1-4-alkyl;
• R6b represents hydrogen, or C1-3-alkyl;
• R7 represents C1-5-alkyl;
• R8 represents C1-2-alkyl, or methoxy;
• R9 represents C1-5-alkyl;
• R10 represents C1-2-alkyl;
• A represents
• wherein the asterisks indicate the bond that is linked to the Pyridine1 ring;
• Pyridine2 represents
• wherein the asterisks mark the bond with which the Pyridine2 ring is bound to A;
• R11 represents C1-4-alkyl, C1-3-alkoxy, hydroxymethyl, or NR11aR11b;
• R11a represents C1-3-alkyl;
• R11b represents hydrogen, or C1-2-alkyl;
• R12 represents hydrogen, or C1-2-alkyl;
• R13 represents C1-4-alkyl, or NR13aR13b;
• R13a represents C1-3-alkyl;
• R13b represents hydrogen, or C1-2-alkyl;
• R14 represents C1-2-alkyl;
• R15 represents C1-2-alkyl, or NR15aR15b;
• and R16 represents C1-2-alkyl;
• R15a represents C1-3-alkyl;
• R15b represents hydrogen, or C1-3-alkyl;
• or
• R15 represents C1-2-alkyl;
• and R16 represents C1-4-alkyl, or NR16aR16b;
• R16a represents C1-3-alkyl;
• R16b represents hydrogen, or C1-2-alkyl;
• R17 represents C1-4-alkyl;
• R18 represents C1-2-alkyl, or methoxy;
• R19 represents C1-4-alkyl;
• and
• R20 represents C1-2-alkyl;
• with the exception of 3-(2-ethyl-4-pyridyl)-5-(2-ethyl-4-pyridyl)-1,2,4-oxadiazole;
• in free or salt form.