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US 2011/0212978 A1Published application
Combination of ZD6474 and Pemetrexed
AssigneeAstraZeneca AB
InventorsAnderson Joseph Ryan, Stephen Robert Wedge
Life of this patent
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AssigneeAstraZeneca AB
InventorsAnderson Joseph Ryan, Stephen Robert Wedge
Estimating the term…
The present invention relates to a method for the production of an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal such as a human which is optionally being treated with ionising radiation, particularly a method for the treatment of a cancer, particularly a cancer involving a solid tumour, which comprises the administration of ZD6474 in combination with pemetrexed; to a pharmaceutical composition comprising ZD6474 and pemetrexed; to a combination product comprising ZD6474 and pemetrexed for use in a method of treatment of a human or animal body by therapy; to a kit comprising ZD6474 and pemetrexed; to the use of ZD6474 and pemetrexed in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal such as a human which is optionally being treated with ionising radiation.
1-8. (canceled)
A pharmaceutical composition which comprises ZD6474 or a pharmaceutically acceptable salt thereof, and pemetrexed in association with a pharmaceutically acceptable excipient or carrier.
A kit comprising ZD6474 or a pharmaceutically acceptable salt thereof and pemetrexed.
11-12. (canceled)
A method for treating a cancer involving a solid tumour in a warm blooded animal in need thereof, which comprises administering to said animal an effective amount of ZD6474 or a pharmaceutically acceptable salt thereof, before, after or simultaneously with an effective amount of pemetrexed.
A method for treating a cancer involving a solid tumour in a warm blooded animal in need thereof, which comprises administering to said animal an effective amount of ZD6474 or a pharmaceutically acceptable salt thereof, before, after or simultaneously with an effective amount of pemetrexed and before, after or simultaneously with an effective amount of ionising radiation.
Dependencies are inferred from the claim text.