Antiviral compounds and methods of making and using thereof
AssigneeThe University of Hong Kong
InventorsYi Tsun Richard Kao, Dan Yang, Kwok-Yung Yuen
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Abstract
Compounds which exhibit antiviral activity, particularly against influenza virus, and methods of making and using thereof are described herein. In one embodiment, the compounds are heterocyclic amides containing piperazine and isozazole rings and optionally substituted with one or more substituents. The compounds can be formulated with one or more pharmaceutically acceptable excipients to form compositions suitable for enteral or parenteral administration. The compounds are preferably used to treat or prevent Influenza A infections, such as H1N1, H2N2, H3N2, H5N1, H7N7, H1N2, H9N2, H7N2, H7N3, and H10N7.
Claims39
An antiviral compound of formula I:
- Ar1—Y—Ar2—X—W—Z—Ar3 (formula I)
- wherein Ar1, Ar2, and Ar3 are each independently substituted or unsubstituted aryl or heteroaryl groups;
- X, Y, and Z are independently absent (i.e, a direct bond) or selected from —C(═O)—, —S(═O)—, —SO2—, —N(R1)—, —C(R2)═C(R3)—, and —C(R4R5)n—,
- wherein n is 0 to 6 and wherein R1-R5 are each independently selected from hydrogen;
- hydroxyl;
- halogen;
- substituted or unsubstituted amino;
- —CN;
- —NO2;
- —COOH;
- carboxylate;
- —COR, —COOR, or —CON(R)2;
- substituted or unsubstituted aryl;
- substituted or unsubstituted, linear or branched C1-C6 alkyl;
- substituted or unsubstituted, linear or branched C1-C6 alkenyl;
- substituted or unsubstituted, linear or branched C1-C6 alkynyl;
- substituted or unsubstituted C3-C6 cycloalkyl or cycloalkenyl;
- or substituted or unsubstituted, linear and branched C1-C6 alkoxy;
- and
- W is a linear or cyclic or heterocylic group.
Dependencies are inferred from the claim text.