Compounds that modulate intracellular calcium

A compound of Formula (I):

• wherein:
• A is phenyl or benzofuran, wherein phenyl and benzofuran are each optionally substituted with at least one R;
• or A is phenyl substituted with two R groups on adjacent carbon atoms wherein the two R groups and the carbon atoms to which they are attached form a C4-C8cycloalkyl or C3-C8heterocycloalkyl;
• R is selected from F, Cl, Br, I, —CN, —NO2, —CF3, —OH, —OR3, —OCF3, —C═CH, —C═CR3, C1-C6alkylenealkyne, C1-C6alkyl, C3-C6cycloalkyl, C1-C6heteroalkyl, C1-C6haloalkyl, tetrazolyl, C2-C6heterocycloalkyl, phenyl, —NHS(═O)2R3, S(═O)2N(R4)2, —C(═O)CF3, —C(═O)NHS(═O)2R3, —S(═O)2NHC(═O)R4, N(R4)2, —N(R4)C(═O)R3, —CO2R4, —C(═O)R3, —OC(═O)R3, —C(═O)N(R4)2, —SR3, —S(═O)R3, and —S(═O)2R3;
• J is a bond, NHS(═O)2, S(═O)2N(R4), —C(═O), —C(═O)NHS(═O)2, —S(═O)2NHC(═O), N(R4), —N(R4)C(═O), —CO2, —C(═O), —OC(═O), —C(═O)N(R4), —S, —S(═O), and —S(═O)2, C1-C6alkylene, C2-C6alkenylene, C2-C6alkynylene, C1-C6heteroalkylene, C3-C6cycloalkylene, or C2-C6heterocycloalkylene, wherein C1-C6alkylene, C2-C6alkenylene, C2-C6alkynylene, C1-C6heteroalkylene, C3-C6cycloalkylene, and C2-C6heterocycloalkylene is optionally substituted with at least one R;
• R1 is CO2R2 or a carboxylic acid bioisostere, wherein R2 is hydrogen, C1-C6alkyl, C1-C6cycloalkyl, C1-C6haloalkyl, phenyl or benzyl;
• Z is O, S, NH, N—CN, or CHNO2;
• X is W-L-phenyl, W-L-B, B, W-L-D, or D wherein phenyl, B, and D are each optionally substituted with at least one R;
• W is NR2, O or a bond;
• L is methylene, ethylene substituted with at least one R, C3-C6alkylene, C2-C6alkenylene, C2-C6alkynylene, C1-C6heteroalkylene, C3-C6cycloalkylene, or C2-C6heterocycloalkylene, wherein methylene, C3-C6alkylene, C2-C6alkenylene, C2-C6alkynylene, C1-C6heteroalkylene, C3-C6cycloalkylene, and C2-C6heterocycloalkylene is optionally substituted with at least one R;
• B is selected from furan, thiophene, pyrrole, pyridine, oxazole, thiazole, imidazole, thiadiazole, isoxazole, isothiazole, pyrazole, pyridazine, pyrimidine, pyrazine, oxadiazole, thiadiazole, triazole, indole, benzoxazole, benzothiazole, benzimidazole, benzoxadiazole, benzothiadiazole, benzotriazole, pyrazolopyridine, imidazopyridine, pyrrolopyridine, pyrrolopyrimidine, indolizine, purine, furopyridine, thienopyridine, furopyrrole, furofuran, thienofuran, 1,4-dihydropyrrolopyrrole, thienopyrrole, thienothiophene, quinoline, isoquinoline, furopyrazole, thienopyrazole, and 1,6-dihydropyrrolopyrazole;
• D is C3-C10cycloalkyl or C2-C9heterocycloalkyl;
• each R3 is independently selected from C1-C6alkyl, C1-C6haloalkyl, C3-C8cycloalkyl, phenyl, and benzyl;
• each R4 is independently selected from hydrogen, C1-C6alkyl, C1-C6haloalkyl, C3-C8cycloalkyl, phenyl, and benzyl;
• or
• a pharmaceutically acceptable salt, solvate, N-oxide or prodrug thereof.