Phenethylamide derivatives and their heterocyclic analogues

A compound of formula (I)

• wherein
• R1 represents hydrogen, hydroxy or (C3-6)cycloalkyl-amino;
• R2 represents hydrogen or (C1-4)alkyl;
• R3 represents (C3-6)cycloalkyl or (C3-6)cycloalkyl-(C1-4)alkyl;
• or a (C1-4)alkyl-group, which group is unsubstituted or monosubstituted with (C1-4)alkoxy, hydroxy, NR4R5, C(O)NR4R5 or COOR6;
• or a (C1-4)fluoroalkyl-group;
• R4 represents hydrogen or (C1-4)alkyl;
• R5 represents hydrogen or (C1-4)alkyl;
• R6 represents (C1-4)alkyl;
• A represents aryl or heterocyclyl, wherein the aryl or heterocyclyl is independently unsubstituted or mono-, di-, or tri-substituted, wherein the substituents are indepen-dently selected from the group consisting of (C1-4)alkyl, (C1-4)alkoxy, (C1-4)alkylthio, hydroxy, amino, halogen, (C1-4)fluoroalkyl, and (C1-4)fluoroalkoxy;
• or A represents a benzo[1,3]dioxolyl- or a 2,3-dihydro-benzo[1,4]dioxinyl-group wherein said groups are unsubstituted, mono- or di-substituted with halogen;
• or A represents a 5H-[1,3]dioxolo[4,5-f]indole group;
• B represents a group selected from
• wherein
• X represents hydrogen, (C1-4)alkyl, (C3-6)cycloalkyl, (C1-4)alkoxy, R4R5N—CH2—, NR4R5, or halogen;
• Y represents hydrogen or (C1-4)alkyl;
• D represents aryl, wherein the aryl is unsubstituted or mono-, di-, or tri-substituted, wherein the substituents are independently selected from the group consisting of (C1-4)alkyl, (C1-4)alkoxy, hydroxy-(C1-4)alkyl, (C1-2)alkoxy-(C1-4)alkoxy, halogen, (C1-4)fluoroalkyl, NMe2, (C1-4)alkyl-C(O)NH— and cyano;
• or D represents heterocyclyl, wherein the heterocyclyl is unsubstituted or mono- or di-substituted, wherein the substituents are independently selected from the group consisting of (C1-4)alkyl, (C1-4)alkoxy, hydroxy-(C1-4)alkyl, halogen, and (C1-4)alkyl-thio;
• with the proviso that A represents an optionally mono- or disubstituted indol-3-yl group, wherein the substituents are independently selected from the group consisting of (C1-4)alkyl, (C1-4)alkoxy and halogen, if B represents a group of formula
• in a free or a pharmaceutically acceptable salt form.