New compounds for the treatment of cns disorder

A compound of formula (I)

• wherein
• R1 is selected independently for each R1 from the group R1a consisting of Hydrogen, fluorine, chlorine, bromine, NC—, F3C—, HF2C—, FH2C—, F3C—CH2—, carboxy-, C1-6-alkyl-, C2-6-alkenyl-, C2-6-alkynyl-, C1-6-alkyl-S—, C1-6-alkyl-S—C1-3-alkyl-, C3-7-cycloalkyl-, C3-7-cycloalkyl-C1-6-alkyl-, C3-7-cycloalkyl-C2-6-alkenyl-, C3-7-cycloalkyl-C2-6-alkynyl-, C3-7-heterocyclyl-, C3-7-heterocyclyl-C1-6-alkyl-, C3-7-heterocyclyl-C2-6-alkenyl-, C3-7-heterocyclyl-C2-6-alkynyl-, aryl, aryl-C1-6-alkyl-, aryl-C2-6-alkenyl-, aryl-C2-6-alkynyl-, heteroaryl-, heteroaryl-C1-6-alkyl-, heteroaryl-C2-6-alkenyl-, heteroaryl-C2-6-alkynyl-, heterocyclyl-CO—, R10—O—, R10—O—C1-3-alkyl-, (R10)2N—, R10O—CO—, (R9)2N—CO—, R10—CO—(R10)N—, R10—CO—, (R9)2N—CO—(R10)N—, (R9)2N—CO—O—, R10—O—CO—(R10)N—, R10—SO2—(R10)N—, and C1-6-alkyl-SO2—,
• where the above-mentioned members HF2C—, FH2C—, F3C—CH2—, C1-6-alkyl-, C2-6-alkenyl-, C2-6-alkynyl-, C1-6-alkyl-S—C1-3-alkyl-, C3-7-cycloalkyl-, C3-7-cycloalkyl-C1-6-alkyl-, C3-7-cycloalkyl-C2-6-alkenyl-, C3-7-cycloalkyl-C2-6-alkynyl-, C3-7-heterocyclyl-, C3-7-heterocyclyl-C1-6-alkyl-, C3-7-heterocyclyl-C2-6-alkenyl-, C3-7-heterocyclyl-C2-6-alkynyl-, aryl, aryl-C1-6-alkyl-, aryl-C2-6-alkenyl-, aryl-C2-6-alkynyl-, heteroaryl-, heteroaryl-C1-6-alkyl-, heteroaryl-C2-6-alkenyl-, heteroaryl-C2-6-alkynyl-, R10—O—C1-3-alkyl-, heterocyclyl-CO—, and C1-6-alkyl-SO2— may optionally be substituted independently of one another by one or more substituents selected independently of one another from the group consisting of fluorine, chlorine, bromine, OH—, NC—, O2N—, F3C—, HF2C—, FH2C—, F3C—CH2—, HO—C1-6-alkyl-, C1-6-alkyl-O—, C1-6-alkyl-O—C1-6-alkyl-, (R10)2N—, (R13)2N—C1-3-alkyl-, (R10)2N—CO—, C3-6-cycloalkyl-, C3-6-cycloalkyl-C1-4-alkyl-, and C1-6-alkyl-, preferably from the group consisting of fluorine, chlorine, bromine, OH—, NC—, O2N—, F3C—, HF2C—, FH2C—, F3C—CH2—, HO—C1-6-alkyl-, C1-6-alkyl-O—, C1-6-alkyl-O—C1-6-alkyl-, (R10)2N—, (R13)2N—C1-3-alkyl-, (R10)2N—CO—, C3-6-cycloalkyl-, and C3-6-cycloalkyl-C1-4-alkyl-,
• L is selected from the integers 0, 1, 2 and 3,
• x is selected from the integers 0, 1, 2, 3 and 4,
• y is selected from the integers 0, 1 and 2,
• D is selected from the group D1a consisting of heterocyclyl,
• wherein the above-mentioned members of the group D1a may optionally be substituted by one or more substituents selected independently of one another from the group R2 and/or optionally substituted by one group R3
• or
• D is selected from the group D2a consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl cyclooctyl, cyclobutenyl, cyclopentenyl, cyclohexenyl, cycloheptenyl, cyclooctenyl, cyclopentadienyl, cyclohexadienyl, cycloheptadienyl, cyclooctadienyl, cycloheptatrienyl, cyclooctatrienyl and cyclooctatetraenyl,
• wherein the above-mentioned members of the group D2a may optionally be substituted by one or more substituents selected independently of one another from the group R4,
• or
• D is selected from the group D3a consisting of C1-8-alkyl
• wherein the above-mentioned C1-8-alkyl-group D3a may optionally be substituted by one or more substituents selected independently of one another from the group R5.
• or
• D is selected from the group D4a consisting of aryl
• wherein the above-mentioned aryl group D4a may optionally be substituted by one or more substituents selected independently of one another from the group consisting of R6. Preferred are such compounds wherein D4a is substituted by not more than one R6.
• or
• D is selected from the group D5a consisting of heteroaryl
• wherein the above-mentioned members of the group D5a may optionally be substituted by one or more substituents selected independently of one another from the group R6. Preferred are such compounds wherein D5a is substituted by not more than one R6.
• R2 is selected from the group R2a consisting of
• H—, fluorine, NC—, F3C—, HF2C—, FH2C—, F3C—CH2—, carboxy-, C1-6-alkyl-, C2-6-alkenyl-, C2-6-alkynyl-, C1-6-alkyl-S—, C1-6-alkyl-S—C1-3-alkyl-, C3-7-cycloalkyl-, C3-7-cycloalkyl-C1-6-alkyl-, C3-7-cycloalkyl-C2-6-alkenyl-, C3-7-cycloalkyl-C2-6-alkynyl-, C3-7-heterocyclyl-, C3-7-heterocyclyl-C1-6-alkyl-, C3-7-heterocyclyl-C2-6-alkenyl-, C3-7-heterocyclyl-C2-6-alkynyl-, aryl, aryl-C1-6-alkyl-, aryl-C2-6-alkenyl-, aryl-C2-6-alkynyl-, heteroaryl, heteroaryl-C1-6-alkyl-, heteroaryl-C2-6-alkenyl-, heteroaryl-C2-6-alkynyl-, R10—O—C2-3-alkyl-, (R10)2N—, (R10)2N—C1-3-alkyl-, R10O—CO—, (R10)2N—CO—, R10—CO—(R10)N—, R10—CO—, (R10)2N—CO—(R10)N—, R10—O—CO—(R10)N—, R10—SO2—(R10)N—, C1-6-alkyl-SO2—, and oxo,
• where the above-mentioned members HF2C—, FH2C—, F3C—CH2—, C1-6-alkyl-(preferably C2-6-alkyl), C2-6-alkenyl-, C2-6-alkynyl-, C1-6-alkyl-S—C1-3-alkyl-, C3-7-cycloalkyl-, C3-7-cycloalkyl-C1-6-alkyl-, C3-7-cycloalkyl-C2-6-alkenyl-, C3-7-cycloalkyl-C2-6-alkynyl-, C3-7-heterocyclyl-, C3-7-heterocyclyl-C1-6-alkyl-, C3-7-heterocyclyl-C2-6-alkenyl-, C3-7-heterocyclyl-C2-6-alkynyl-, aryl, aryl-C1-6-alkyl-, aryl-C2-6-alkenyl-, aryl-C2-6-alkynyl-, heteroaryl, heteroaryl-C1-6-alkyl-, heteroaryl-C2-6-alkenyl-, heteroaryl-C2-6-alkynyl-, R10—O—C2-3-alkyl-, (R10)2N—C1-3-alkyl-, and C1-6-alkyl-SO2— may optionally be substituted independently of one another by one or more substituents selected independently of one another from the group consisting of
• fluorine, chlorine, bromine, NC—, O2N—, F3C—, HF2C—, FH2C—, F3C—CH2—, HO—C1-6-alkyl-, C1-6-alkyl-O—, C1-6-alkyl-O—C1-6-alkyl-, C1-6-alkyl-, (R10)2N—, (R10)2N—C1-3-alkyl-, and (R10)2N—CO—,
• and in cases in that D1 is a heterocyclyl group with NR2 as ring member, R2 shall be
• independently of any other R2:
• H—, F3C—CH2—, HF2C—CH2—, C1-6-alkyl-, C2-6-alkenyl-, C2-6-alkynyl-, C1-6-alkyl-S—C1-3-alkyl-, C3-7-cycloalkyl-, C3-7-cycloalkyl-C1-6-alkyl-, C3-7-cycloalkyl-C2-6-alkenyl-, C3-7-cycloalkyl-C2-6-alkynyl-, C3-7-heterocyclyl-, C3-7-heterocyclyl-C1-6-alkyl-, C3-7-heterocyclyl-C2-6-alkenyl-, C3-7-heterocyclyl-C2-6-alkynyl-, aryl, aryl-C1-6-alkyl-, heteroaryl, heteroaryl-C1-6-alkyl-, R10—O—C1-3-alkyl-, Rub-CO—, (R10)2N—CO—, R10—CO—, R10—SO2—, and C1-6-alkyl-SO2—,
• where the above-mentioned members F3C—CH2—, HF2C—CH2—, C1-6-alkyl-, C2-6-alkenyl-, C2-6-alkynyl-, C1-6-alkyl-S—C1-3-alkyl-, C3-7-cycloalkyl-, C3-7-cycloalkyl-C1-6-alkyl-, C3-7-cycloalkyl-C2-6-alkenyl-, C3-7-cycloalkyl-C2-6-alkynyl-, C3-7-heterocyclyl-, C3-7-heterocyclyl-C1-6-alkyl-, C3-7-heterocyclyl-C2-6-alkenyl-, C3-7-heterocyclyl-C2-6-alkynyl-, aryl, aryl-C1-6-alkyl-, heteroaryl, heteroaryl-C1-6-alkyl-, R10—O—C1-3-alkyl-, and C1-6-alkyl-SO2— may optionally be substituted independently of one another by one or more substituents selected independently of one another from the group consisting of
• fluorine, HO—, NC—, O2N—, F3C—, HF2C—, FH2C—, F3C—CH2—, HO—C1-6-alkyl-, R10—O—C1-6-alkyl-, C1-6-alkyl-, R10—O—, (R10)2N—, (R10)2N—C1-3-alkyl-, and (R10)2N—CO—,
• R3 is selected from the group R1a consisting of
• H—, HO— and R10—O—,
• R4 is selected from the group R4a consisting of
• H—, fluorine, chlorine, bromine, HO—, NC—, F3C—, HF2C—, FH2C—, F3C—CH2—, carboxy-, C1-6-alkyl-, C2-6-alkenyl-, C2-6-alkynyl-, C1-6-alkyl-S—, C1-6-alkyl-S—C1-3-alkyl-, C3-7-cycloalkyl-, C3-7-cycloalkyl-C1-6-alkyl-, C3-7-cycloalkyl-C2-6-alkenyl-, C3-7-cycloalkyl-C2-6-alkynyl-, C3-7-heterocyclyl-, C3-7-heterocyclyl-C1-6-alkyl-, C3-7-heterocyclyl-C2-6-alkenyl-, C3-7-heterocyclyl-C2-6-alkynyl-, aryl, aryl-C1-6-alkyl-, aryl-C2-6-alkenyl-, aryl-C2-6-alkynyl-, heteroaryl-, heteroaryl-C1-6-alkyl-, heteroaryl-C2-6-alkenyl-, heteroaryl-C2-6-alkynyl-, R10—O—, R10—O—C1-3-alkyl-, (R10)2N—, (R10)2N—C1-3-alkyl-, R10O—CO—, (R10)2N—CO—, R10—CO—(R10)N—, R10—CO—, (R10)2N—CO—(R10)N—, R10—O—CO—(R10)N—, R10—SO2—(R10)N—, and C1-6-alkyl-SO2—,
• where the above-mentioned members HF2C—, FH2C—, F3C—CH2—, C1-6-alkyl-, C2-6-alkenyl-, C2-6-alkynyl-, C1-6-alkyl-S—C1-3-alkyl-, C3-7-cycloalkyl-, C3-7-cycloalkyl-C1-6-alkyl-, C3-7-cycloalkyl-C2-6-alkenyl-, C3-7-cycloalkyl-C2-6-alkynyl-, C3-7-heterocyclyl-, C3-7-heterocyclyl-C1-6-alkyl-, C3-7-heterocyclyl-C2-6-alkenyl-, C3-7-heterocyclyl-C2-6-alkynyl-, aryl, aryl-C1-6-alkyl-, aryl-C2-6-alkenyl-, aryl-C2-6-alkynyl-, heteroaryl-, heteroaryl-C1-6-alkyl-, heteroaryl-C2-6-alkenyl-, heteroaryl-C2-6-alkynyl-, R10—O—C1-3-alkyl-, (R10)2N—C1-3-alkyl-, and C1-6-alkyl-SO2— may optionally be substituted independently of one another by one or more substituents selected from the group consisting of fluorine, chlorine, bromine, NC—, O2N—, F3C—, HF2C—, FH2C—, F3C—CH2—, HO—C1-6-alkyl-, C1-6-alkyl-O—, C1-6-alkyl-O—C1-6-alkyl-, C1-6-alkyl-, (R10)2N—, (R10)2N—C1-3-alkyl-, and (R10)2N—CO—,
• or
• two substituents R4a together form a C2-6-alkylene bridge, wherein one or two CH2 groups of the C2-6-alkylene bridge may be replaced independently of one another by O, S, SO, SO2, N(R10) or N—C(O)—R10 in such a way that in each case two O or S atoms or an O and an S atom are not joined together directly.
• R5 is selected from the group R5a consisting of
• H—, fluorine, chlorine, bromine, HO—, NC—, F3C—, HF2C—, FH2C—, F3C—CH2—, carboxy-, C1-6-alkyl-, C2-6-alkenyl-, C2-6-alkynyl-, C1-6-alkyl-S—, C1-6-alkyl-S—C1-3-alkyl-, C3-7-cycloalkyl-, C3-7-cycloalkyl-C1-6-alkyl-, C3-7-cycloalkyl-C2-6-alkenyl-, C3-7-cycloalkyl-C2-6-alkynyl-, C3-7-heterocyclyl-, C3-7-heterocyclyl-C1-6-alkyl-, C3-7-heterocyclyl-C2-6-alkenyl-, C3-7-heterocyclyl-C2-6-alkynyl-, aryl, aryl-C1-6-alkyl-, aryl-C2-6-alkenyl-, aryl-C2-6-alkynyl-, heteroaryl-, heteroaryl-C1-6-alkyl-, heteroaryl-C2-6-alkenyl-, heteroaryl-C2-6-alkynyl-, R10—, O—, R10—O—C1-3-alkyl-, (R10)2N—, (R10)2N—C1-3-alkyl-, R10O—CO—, (R10)2N—CO—, R10—CO—(R10)N—, R10—CO—, (R10)2N—CO—(R10)N—, R10—O—CO—(R10)N—, R10—SO2—(R10)N—, and C1-6-alkyl-SO2—,
• where the above-mentioned members HF2C—, FH2C—, F3C—CH2—, carboxy-, C1-6-alkyl-, C2-6-alkenyl-, C2-6-alkynyl-, C1-6-alkyl-S—C1-3-alkyl-, C3-7-cycloalkyl-, C3-7-cycloalkyl-C1-6-alkyl-, C3-7-cycloalkyl-C2-6-alkenyl-, C3-7-cycloalkyl-C2-6-alkynyl-, C3-7-heterocyclyl-, C3-7-heterocyclyl-C1-6-alkyl-, C3-7-heterocyclyl-C2-6-alkenyl-, C3-7-heterocyclyl-C2-6-alkynyl-, aryl, aryl-C1-6-alkyl-, aryl-C2-6-alkenyl-, aryl-C2-6-alkynyl-, heteroaryl-, heteroaryl-C1-6-alkyl-, heteroaryl-C2-6-alkenyl-, heteroaryl-C2-6-alkynyl-, R10—O—C1-3-alkyl-, (R10)2N—C1-3-alkyl-, and C1-6-alkyl-SO2—, may optionally be substituted independently of one another by one or more substituents selected from the group consisting of fluorine, chlorine, bromine, NC—, O2N—, F3C—, HF2C—, FH2C—, F3C—CH2—, HO—C1-6-alkyl-, C1-6-alkyl-O—, C1-6-alkyl-O—C1-6-alkyl-, C1-6-alkyl-, (R10)2N—, (R10)2N—C1-3-alkyl-, and (R10)2N—CO—,
• R6 is selected from the group R6a consisting of
• H—, fluorine, chlorine, bromine, HO—, NC—, F3C—, HF2C—, FH2C—, F3C—CH2—, carboxy-, C1-6-alkyl-, C2-6-alkenyl-, C2-6-alkynyl-, C1-6-alkyl-S—, C1-6-alkyl-S—C1-3-alkyl-, C3-7-cycloalkyl-, C3-7-cycloalkyl-C1-6-alkyl-, C3-7-cycloalkyl-C2-6-alkenyl-, C3-7-cycloalkyl-C2-6-alkynyl-, C3-7-heterocyclyl-, C3-7-heterocyclyl-C1-6-alkyl-, C3-7-heterocyclyl-C2-6-alkenyl-, C3-7-heterocyclyl-C2-6-alkynyl-, aryl, aryl-C1-6-alkyl-, aryl-C2-6-alkenyl-, aryl-C2-6-alkynyl-, heteroaryl-, heteroaryl-C1-6-alkyl-, heteroaryl-C2-6-alkenyl-, heteroaryl-C2-6-alkynyl-, R10—O—, R10—O—C1-3-alkyl-, (R10)2N—, (R10)2N—C1-3-alkyl-, R10O—CO—, (R10)2N—CO—, R10—CO—(R10)N—, R10—CO—, (R10)2N—CO—(R10)N—, R10—O—CO—(R10)N—, R10—SO2—(R10)N—, and C1-6-alkyl-SO2—,
• where the above-mentioned members HF2C—, FH2C—, F3C—CH2—, C1-6-alkyl-, C2-6-alkenyl-, C2-6-alkynyl-, C1-6-alkyl-S—C1-3-alkyl-, C3-7-cycloalkyl-, C3-7-cycloalkyl-C1-6-alkyl-, C3-7-cycloalkyl-C2-6-alkenyl-, C3-7-cycloalkyl-C2-6-alkynyl-, C3-7-heterocyclyl-, C3-7-heterocyclyl-C1-6-alkyl-, C3-7-heterocyclyl-C2-6-alkenyl-, C3-7-heterocyclyl-C2-6-alkynyl-, aryl, aryl-C1-6-alkyl-, aryl-C2-6-alkenyl-, aryl-C2-6-alkynyl-, heteroaryl-, heteroaryl-C1-6-alkyl-, heteroaryl-C2-6-alkenyl-, heteroaryl-C2-6-alkynyl-, R10—O—C1-3-alkyl-, (R10)2N—C1-3-alkyl- and C1-6-alkyl-SO2— may optionally be substituted independently of one another by one or more substituents selected from the group consisting of fluorine, chlorine, bromine, NC—, O2N—, F3C—, HF2C—, FH2C—, F3C—CH2—, HO—C1-6-alkyl-, C1-6-alkyl-O—, C1-6-alkyl-O—C1-6-alkyl-, C1-6-alkyl-, (R10)2N—, (R10)2N—C1-3-alkyl-, and (R10)2N—CO—,
• R9 is selected independently for each R9 from the group R9a consisting of H—, F3C—CH2—, C2-6-alkenyl-, C2-6-alkinyl-, C3-7-cycloalkyl-, C3-7-cycloalkyl-C1-3-alkyl-, C3-7-heterocyclyl-, C3-7-heterocyclyl-C1-6-alkyl-, aryl, aryl-C1-3-alkyl-, heteroaryl, heteroaryl-C1-3-alkyl- and C1-6-alkyl-, and
• where the above-mentioned members F3C—CH2—, C2-6-alkenyl-, C2-6-alkinyl-, C3-7-cycloalkyl-, C3-7-cycloalkyl-C1-3-alkyl-, C3-7-heterocyclyl-, C3-7-heterocyclyl-C1-6-alkyl-, aryl, aryl-C1-3-alkyl-, heteroaryl, heteroaryl-C1-3-alkyl- and C1-6-alkyl-, may optionally be substituted independently of one another by one or more substituents selected independently of one another from the group consisting of
• fluorine, chlorine, bromine, HO—, NC—, O2N—, F3C—, HF2C—, FH2C—, F3C—CH2—, HO—C1-6-alkyl-, CH3—O—C1-6-alkyl-, C1-6-alkyl-O— and C1-6-alkyl-,
• R10 is selected independently for each R10 from the group R10a consisting of H— (but not in case is part of a group being selected from R10O—CO—, R10—SO2— or R10—CO—), F3C—CH2—, C1-6-alkyl-, C2-6-alkenyl-, C3-7-cycloalkyl-, C3-7-cycloalkyl-C1-3-alkyl-, C3-7-heterocyclyl-, C3-7-heterocyclyl-C1-6-alkyl-, aryl, aryl-C1-3-alkyl-, heteroaryl, and heteroaryl-C1-3-alkyl-,
• and in case where two R10 groups both are bound to the same nitrogen atom they may together with said nitrogen atom form a 3 to 12 membered heterocyclyl ring, and wherein one of the —CH2-groups of the heterocyclic ring formed may be replaced by —O—, —S—, —NH—, —N(C3-6-cycloalkyl)-, —N(C3-6-cycloalkyl-C1-4-alkyl)- or —N(C1-4-alkyl)- and
• where the above-mentioned members may optionally be substituted independently of one another by one or more substituents selected from the group consisting of
• fluorine, chlorine, bromine, HO—, NC—, O2N—, F3C—, HF2C—, FH2C—, F3C—CH2—, HO—C1-6-alkyl-, CH3—O—C1-6-alkyl-, C1-6-alkyl- and C1-6-alkyl-O—,
• and pharmaceutically acceptable salts thereof.