Treatment of neonate foals with meloxicam
OwnerGiuseppe Pippia, Sharanne Raidalinventors
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Abstract
A method of administering meloxicam containing compositions to neonate foals of 6 weeks of age or less is provided. The inventors have discovered that foals of 6 weeks of age or less can have meloxicam administered at a dosage of 0.6 mg/kg without any negative or adverse reaction by the foal. The method also provides a dosing regimen for obtaining first peak plasma concentrations of approximately 800 ng/ml, average plasma concentration levels of 200 ng/ml for 6 hours after a single dose, and sustained plasma concentration levels of 100 ng/ml with twice daily dosing.
Claims17
A method of administering meloxicam to a foal of 6 weeks of age or less, the method comprising administering an effective amount of a meloxicam containing composition that is sufficient to provide a first peak meloxicam plasma concentration of about 650 ng/mL to 1500 ng/mL about 30 to 60 minutes after providing the dose.
A dosing regimen to obtain meloxicam plasma concentrations of 650 ng/mL to 1500 ng/mL in neonate foals 6 weeks of age or less 30-60 minutes after administration that comprises administering to the foal a dose of meloxicam containing composition to the foal at the rate of at least 0.6 mg of meloxicam per kg of weight of the foal in a single dose.
A dosing regimen to obtain meloxicam plasma concentrations of 800 ng/mL in neonate foals 6 weeks of age or less 30-60 minutes after administration that comprises administering to the foal a dose of meloxicam containing composition to the foal at the rate of at least 0.6 mg of meloxicam per kg of weight of the foal in a single dose.
A dosing regimen to obtain meloxicam plasma concentrations of 200 ng/mL for 6 hours in neonate foals 6 weeks of age or less that comprises administering to the foal a dose of meloxicam containing composition to the foal at the rate of at least 0.6 mg of meloxicam per kg of weight of the foal in a single dose.
A dosing regimen to obtain sustained meloxicam plasma concentrations of 100 ng/mL in neonate foals 6 weeks of age or less that comprises administering to the foal dose of meloxicam containing composition to the foal at the rate of at least 0.6 mg of meloxicam per kg of weight of the foal, twice daily.
Dependencies are inferred from the claim text.