Substituted indole compounds having nos inhibitory activity

A method of treating a condition in a mammal caused by the action of nitric oxide synthase (NOS), wherein said method comprises administering to said mammal an effective amount of compound having the formula:

• or a pharmaceutically acceptable salt or prodrug thereof, wherein,
• R1 is H, optionally substituted C1-6 alkyl, optionally substituted C1-4 alkaryl, optionally substituted C2-9 heterocyclyl, or optionally substituted C1-4 alkheterocyclyl;
• R2 is H, Hal, optionally substituted C1-6 alkyl, optionally substituted C6-10 aryl, optionally substituted C1-4 alkaryl, optionally substituted C2-9 bridged heterocyclyl, optionally substituted C1-4 bridged alkheterocyclyl, optionally substituted C2-9 heterocyclyl, or optionally substituted C1-4 alkheterocyclyl;
• R3 is H, Hal, optionally substituted C1-6 alkyl, optionally substituted C6-10 aryl, optionally substituted C1-4 alkaryl, optionally substituted C2-9 bridged heterocyclyl, optionally substituted C1-4 bridged alkheterocyclyl, optionally substituted C2-9 heterocyclyl, or optionally substituted C1-4 alkheterocyclyl;
• each of R4 and R7 is, independently, H, F, C1-6 alkyl, or C1-6 alkoxy;
• R5 is H, R5AC(NH)NH(CH2)r5 or R5BNHC(S)NH(CH2)r5, wherein r5 is an integer from 0 to 2, R5A is optionally substituted C6-10 aryl, optionally substituted C1-4 alkaryl, optionally substituted C2-9 heterocyclyl, optionally substituted C1-4 alkheterocyclyl, optionally substituted C1-6 thioalkoxy, optionally substituted C1-4 thioalkaryl, optionally substituted aryloyl, or optionally substituted C1-4 thioalkheterocyclyl;
• R5B is optionally substituted C1-6 thioalkoxy, optionally substituted C1-4 thioalkaryl, or optionally substituted C1-4 thioalkheterocyclyl;
• and
• R6 is H or R6AC(NH)NH(CH2)r6 or R6BNHC(S)NH(CH2)r6, wherein r6 is an integer from 0 to 2, R6A is optionally substituted C1-6 alkyl, optionally substituted C6-10 aryl, optionally substituted C1-4 alkaryl, optionally substituted C2-9 heterocyclyl, optionally substituted C1-4 alkheterocyclyl, optionally substituted C1-6 thioalkoxy, optionally substituted C1-4 thioalkaryl, optionally substituted aryloyl, or optionally substituted C1-4 thioalkheterocyclyl;
• R6B is optionally substituted C6-10 aryl, optionally substituted C2-9 heterocyclyl, optionally substituted C1-4 alkheterocyclyl, optionally substituted C1-6 thioalkoxy, optionally substituted C1-4 thioalkaryl, optionally substituted aryloyl, or optionally substituted C1-4 thioalkheterocyclyl;
• wherein one, but not both, of R5 and R6 is H.