Azabiphenylaminobenzoic acid derivatives as dhodh inhibitors

A compound of formula (I):

• wherein:
• R1 is chosen from a hydrogen atoms, halogen atoms, C1-4 alkyl, C3-4 cycloalkyl, —CF3 and —OCF3,
• R2 is chosen from a hydrogen atoms, halogen atoms and C1-4 alkyl groups,
• R3 is chosen from COOR5, —CONHR5, tetrazolyl, —SO2NHR5 and —CONHSO2R5 groups, wherein R5 is chosen from a hydrogen atom and linear or branched C1-4 alkyl groups,
• R4 is chosen from a hydrogen atom and C1-4 alkyl groups.
• R9 is chosen from a hydrogen atom and phenyl groups,
• G1 represents a group chosen from N and CR6, wherein R6 is chosen from a hydrogen atoms, halogen atoms, C1-4 alkyl groups, C3-4 cycloalkyl groups, C1 alkoxy groups, —CF3, —OCF3, monocyclic N-containing C5-7 heteroaryl groups, monocyclic N-containing C3-7 heterocyclyl groups and C6-10 aryl groups which are optionally substituted with at least one substituents chosen from halogen atoms and C1-4 alkyl groups,
• G2 represents a group chosen from:
• a hydrogen atom, hydroxy groups, halogen atoms, C3-4 cycloalkyl groups, C1-4 alkoxy groups and —NRaRb, wherein
• Ra is chosen from C1-4 alkyl groups, and Rb is chosen from C1-4 alkyl groups and C1-4 alkoxy-C1-4 alkyl groups, or Ra and Rb together with the nitrogen atom to which they are attached form a saturated 6 to 8 membered heterocyclic ring optionally containing one oxygen atom as an additional heteroatom,
• a monocyclic or bicyclic 5 to 10 membered heteroaromatic ring containing one or more nitrogen atoms, which is optionally substituted by at least one substituents chosen from halogen atoms, C1-4 alkyl groups, C1-4 alkoxy groups, C3-4 cycloalkyl groups, C3-4 cycloalkoxy groups, —CF3, —OCF3, and —CONR7R8, wherein R7 and R8 are independently chosen from a hydrogen atom, linear or branched C1-4 alkyl groups, C3-7 cycloalkyl groups, or R7 and R8 together with the nitrogen atom to which they are attached form a group of formula
• wherein n is an integer from 0 to 3, and
• a phenyl group, which is optionally substituted by at least one substituents chosen from halogen atoms, C1-4 alkyl groups, hydroxyl, C1-4 alkoxy groups, C3-4 cycloalkyl groups, C3-4 cycloalkoxy groups, cyano groups, —CF3, —OCF3, —CONR7R8, oxadiazolyl groups, triazolyl groups, pyrazolyl groups and imidazolyl groups, wherein the oxadiazolyl, triazolyl, pyrazolyl and imidazolyl groups are optionally substituted by C1-4 alkyl groups or C3-7 cycloalkyl groups and wherein R7 and R8 are independently chosen from a hydrogen atom, linear or branched C1-4 alkyl groups, and C3-7 cycloalkyl groups, or R7 and R8 together with the nitrogen atom to which they are attached form a group of formula
• wherein n is an integer from 0 to 3
• or, G2 together with R6 forms a non-aromatic C5-10 carbocyclic group or a C6-10 aryl group,
• or a pharmaceutically acceptable salts or N-oxides thereof.