Protein Kinase Inhibitors

A compound having the following structure (I):

• or a steroisomer, prodrug or pharmaceutically acceptable salt thereof,
• wherein
• A is a ring moiety selected from:
• X is NH, S or O;
• Z is CH or N;
• R1 and R2 are the same or different and are independently hydrogen, hydroxyl, halo, —CN, —NO2, —NH2, —R, —OR, —SCH3, —CF3, —C(═O)OR or —OC(═O)R, where R is alkyl or substituted alkyl;
• R3 is hydrogen, —NH2, alkyl, —CN, or —NO2, or R3 is -L3-Cycl3 wherein L3 is a direct bond, S or NH, and Cycl3 is a carbocycle, substituted carbocycle, heterocycle or substituted heterocycle;
• L1 is a direct bond, —NR′—, —OC(═S)NH— or —NHC(═S)O—, wherein R′ is H or alkyl;
• Cycl1 is a carbocycle, substituted carbocycle, heterocycle or substituted heterocycle;
• L2 is a direct bond or —C(═S)NH—, —NHC(═S)—, —NHC(═S)NH—, —C(═O)NH—, —NHC(═O)—, —NHC(═O)NH—, —(CH2)n—, —NH(CH2)n—, —(CH2)nNH—, —NH(CH2)nNH—, —C(═S)NH(CH2)n—, —NHC(═S)(CH2)n—, —(CH2)nC(═S)NH(CH2)n—, —(CH2)nNHC(═S)(CH2)n—, —NHC(═O)—, —S(═O)2—, —S(═O)2NH—, —NHS(═O)2—, wherein n is, at each occurrence the same or different and independently 1, 2, 3 or 4;
• and
• Cycl2 is a carbocycle, substituted carbocycle, heterocycle or substituted heterocycle.