Processes for the preparation of phosphatide salts
AssigneeLipogen Ltd.
InventorDavid Rutenberg
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AssigneeLipogen Ltd.
InventorDavid Rutenberg
Estimating the term…
The present invention discloses processes a process for the preparation of phosphatide-salt complexes, the process including the steps of: using at least one raw material lecithin as a substrate; and enzymatically processing at least one raw material lecithin with phospholipase-D, racemic or enantiomerically-pure serine, and/or amine in an aqueous carboxylate-salt-complex solution, wherein the step of processing is performed in a single-phase reaction environment, to produce phosphatide-salt complexes having a structural fatty-acid chain derived from at least one raw material lecithin. Preferably, the step of processing is performed at a pH in the range of about 4.5-8.0 at a temperature in the range of about 25-60° C. Preferably, the aqueous carboxylate-salt-complex solution is formed from an aqueous solution of a carboxylic acid with a chain length of C2-C8 and a salt in an approximately 1:2 (weight per weight) acid-to-salt ratio.
A process for the preparation of phosphatide-salt complexes, the process comprising the steps of:
A process for the simultaneous preparation of a mixture of phosphatide-salt complexes including phosphatidic-acid-salt (PA-salt) complex and phosphatidylserine-salt (PS-salt) complex, the process comprising the steps of:
Dependencies are inferred from the claim text.