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US 2011/0212915 A1Published application
Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
AssigneeAventis Pharma S.A.
InventorsVesna Biberovic, Luc Grondard, Pierre Mourier, Christian VISKOV
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Abstract
The present invention relates to mixtures of polysaccharides derived from heparin having a mean molecular weight of 1500 to 3000 Daltons and an anti-Xa/anti-IIa ratio greater than 30, their method of preparation and pharmaceutical compositions containing them.
Claims17
1-53. (canceled)
A mixture of sulfated oligosaccharides having the following characteristics:
- a mean molecular weight of from about 1500 daltons to about 3000 daltons,
- an anti-Xa activity of between 150.5 IU/mg and 200 IU/mg,
- an anti-IIa activity of less than about 10 IU/mg, and
- an anti-Xa activity/anti-IIa activity ratio of greater than about 30;
- wherein the constituent oligosaccharides of the mixture:
- contain 2 to 26 saccharide units,
- have a 4,5-unsaturated uronic acid 2-0-sulfate unit at one of their ends,
- contain a hexasaccharide fraction, wherein from about 8% to about 15% of the hexasaccharide fraction of the mixture is the hexasaccharide ΔIIa-IIs-Is of formula:
- and are in the form of at least one salt chosen from alkali and alkaline earth metal salts.
6 more elements
Dependencies are inferred from the claim text.