Optimised formulation of tobramycin for aerosolization
AssigneeChiesi Farmaceutici S.p.A.
InventorsChiara Malvolti, Raffaella Garzia
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Abstract
The invention provides a tobramycin formulation for delivery by aerosolization in the form of additive-free, isotonic solution whose pH has been optimised to ensure adequate shelf-life at room temperature. Said formulation can be advantageously used for the treatment and prophylaxis of acute and chronic endobronchial infections, in particular those caused by the bacterium Pseudomonas aeruginosa associated to lung diseases such as cystic fibrosis.
Claims10
A method for treating a lung infection, said method comprising administering an effective amount of an aerosol formulation to a subject in need thereof, said aerosol formulation comprising:
- 75 mg/ml of tobramycin dissolved in an aqueous solution containing 0.45% w/v of sodium chloride;
- wherein the pH is between 4.5 and 5.5 and the osmolarity ranges between 250 and 450 mOsm/l, and
- said formulation is free of preservatives and anti-oxidants.
Dependencies are inferred from the claim text.