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US 2011/0212911 A1Published application
Transcription factor inhibitors and related compositions, formulations and methods
AssigneesThe Ohio State University, Nationwide Children's Hospital, Inc.
InventorsPui-Kai Li, Chenglong Li, Jiayuh Lin
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Abstract
The present invention provides small molecules useful to affect cancer cells, along with related methods. The present compounds, formulations, kits and methods are useful for a variety of research, diagnostic and therapeutic purposes. STAT3 inhibitors, particularly LLL12, are disclosed. The STAT3 inhibitors are useful to treat breast cancer in general and breast cancer initiating cells in particular.
Claims40
A compound having the general formula I:
- wherein
- i. R1, R2 are independently hydrogen or alkylM, wherein M is 1, 2, 3, 4, 5 or 6 carbons;
- ii. R3, R5, R6, R8, R9 are independently hydrogen, alkyl, alkoxy, halogen, NO2, NH2, or hydroxyl;
- and
- iii. R4, R7 are independently alkyl, alkoxy, O-alkyl, N-alkyl, aromatic, heteroaromatic, cyclic, or heterocyclic.
2 more elements
Dependencies are inferred from the claim text.