Peptides for the treatment of oxidative stress related disorders
AssigneeRamot at Tel-Aviv University Ltd.
InventorsDaniel Offen, Nirit Lev, Eldad Melamed
Life of this patent
Estimating the term…
Abstract
Isolated DJ-1 related peptides are disclosed and pharmaceutical compositions comprising same for treating oxidative stress-related disorder.
Claims24
1-38. (canceled)
An isolated peptide, or peptide mimetic thereof, being no longer than 25 amino acids comprising a sequence as set forth in SEQ ID NO:
- 3, wherein the isolated peptide increases viability of a cell under oxidative stress conditions.
An isolated peptide, or peptide mimetic thereof, no longer than 25 amino acids comprising at least 2 consecutive amino acids from the amino acid sequence as set forth in SEQ ID NO:
- 1, and a pharmaceutically acceptable carrier, wherein the isolated peptide increases viability of a cell under oxidative stress conditions.
An isolated peptide, or peptide mimetic thereof, no longer than 25 amino acids comprising at least 2 consecutive amino acids from the amino acid sequence as set forth in SEQ ID NO:
- 2, wherein the isolated peptide increases viability of a cell under oxidative stress conditions.
A pharmaceutical composition comprising an isolated peptide, or peptide mimetic thereof, no longer than 25 amino acids comprising at least 2 consecutive amino acids from the amino acid sequence as set forth in SEQ ID NO:
- 1, and a pharmaceutically acceptable carrier, wherein the isolated peptide increases viability of a cell under oxidative stress conditions.
A pharmaceutical composition comprising an isolated peptide, or peptide mimetic thereof, no longer than 25 amino acids comprising at least 2 consecutive amino acids from the amino acid sequence as set forth in SEQ ID NO:
- 2, and a pharmaceutically acceptable carrier, wherein the isolated peptide increases viability of a cell under oxidative stress conditions.
A pharmaceutical composition comprising an isolated peptide or peptide mimetic thereof comprising an amino acid sequence as set forth in SEQ ID NO:
- 24, and a pharmaceutically acceptable carrier.
A method of treating an oxidative stress-related disorder in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an isolated peptide, or peptide mimetic thereof, no longer than 25 amino acids comprising at least 2 consecutive amino acids from the amino acid sequence as set forth in SEQ ID NO:
- 1, and a pharmaceutically acceptable carrier, wherein the isolated peptide increases viability of a cell under oxidative stress conditions, thereby treating the oxidative stress-related disorder.
A method of treating an oxidative stress-related disorder in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an isolated peptide, or peptide mimetic thereof, no longer than 25 amino acids comprising at least 2 consecutive amino acids from the amino acid sequence as set forth in SEQ ID NO:
- 2, and a pharmaceutically acceptable carrier, wherein the isolated peptide increases viability of a cell under oxidative stress conditions, thereby treating the oxidative stress-related disorder.
Dependencies are inferred from the claim text.