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US 2011/0212891 A1Published application
Azepinone derivatives
AssigneeMsd K.K.
InventorsOsamu Okamoto, Yasuhiro Sasaki, Hitomi Watanabe, Hideki Jona, Kevin D. Dykstra
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Abstract
The present invention relates to a compound represented by formula (I): wherein R1 represents a hydrogen atom or the like; R2 and R3 represent a hydrogen atom or the like; R4 is a group represented by (II) R5 represents a phenyl group which may be substituted with a halogen or the like; m is an integer of from 1 to 3; and p is an integer of from 0 to 4; or a pharmaceutically acceptable salt thereof.
Claims11
A compound of formula I
- wherein:
- R1 is each independently selected from the group consisting of:
- (1) halogen atom,
- (2) lower alkyl group unsubstituted or substituted with one to three halogen atoms, and
- (3) lower alkoxy group unsubstituted or substituted with one to three halogen atoms,
- R2 and R3 are each independently hydrogen atoms, or R2 and R3 taken together form an oxo group;
- R4 is selected from:
- R5 is
- (1) a group selected from the group consisting of phenyl, pyridinyl and thiazolyl,
- or
- (2) a group selected from the group consisting of:
- wherein phenyl, pyridinyl and thiazoly are unsubstituted or substituted with one to three halogen atoms, lower alkoxy groups or trifluoromethyl groups;
- m is an integer of from 1 to three;
- p is an integer of from 0 to four;
- or a pharmaceutically acceptable salt thereof.
12 more elements
9-10. (canceled)
Dependencies are inferred from the claim text.