Methods of treating obesity using enterostatin
AssigneeHarkness Pharmaceuticals, Inc.
InventorsByron Rubin, Peter C.M. McWilliams
Life of this patent
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Abstract
The present invention provides methods of treating or preventing disorders or conditions associated with enterostatin deficiency by administering to a subject in need thereof an effective amount of enterostatin. The present invention also provides methods of selecting a subject for therapy with enterostatin. Exemplary disorders or conditions associated with enterostatin deficiency include overweight, obesity, metabolic disorders, hypertension, lipid related disorders, and type II diabetes.
Claims30
A method of treating or preventing a disorder or condition associated with enterostatin deficiency in a subject in need thereof, comprising administering to an enterostatin-deficient subject an amount of enterostatin effective for treating or preventing the disorder or condition.
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A method of treating an obese or overweight human with enterostatin, comprising:
- a) determining the amount of enterostatin in a sample from the obese or overweight human, wherein the sample is obtained after the obese or overweight human is fed;
- b) selecting the obese or overweight human only if the amount of enterostatin in the sample of the obese or overweight human is less than 50% of a normal enterostatin value;
- and c) administering enterostatin to the selected obese or overweight human.
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A method of reducing food intake in an enterostatin-deficient human in need thereof, comprising (a) determining the amount of enterostatin in a sample from a human;
- (b) selecting the human only if the amount of enterostatin in the sample from the human is less than 50% a normal enterostatin value;
- and (c) administering to the human an amount of enterostatin effective for reducing food intake.
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Dependencies are inferred from the claim text.