Compositions and methods relating to monitoring alcohol consumption and alcohol abuse
AssigneeThe Penn State Research Foundation
InventorsKent E. Vrana, Willard M. Freeman, Kathleen A. Grant, Steve Gonzales
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Abstract
Methods and compositions according to embodiments of the present invention are provided that specifically and sensitively detect alcohol consumption and whether alcohol consumption is moderate or high in a subject. Aspects of the present invention relate to assays of panels of proteins for detecting non-consumption, moderate consumption and high consumption of ethanol by a subject.
Claims27
A method of detecting and characterizing alcohol consumption in a subject, comprising:
- assaying a subject sample for a combination of two or more biomarkers selected from the group consisting of:
- A1BG, A2M, ADIPQ, APCS1, APCS2, APOAI, APOC3, C3, C4a, C9, CALCA, CCL3, CCL4, CD40, CLU, CSF2, CXCL5, EGF, F3, F7, FABP3, FN1, GOT1, HRG, IgE, IGF1, IL12p70, IL18, IL2, IL7, ITIH4, KITLG, KLK3, MMP2, RBP4, SAA4, SERPINF1, THPO, VCAM1 and VEGFA, to determine the level of the two or more biomarkers in the sample;
- and
- comparing the level of the two or more biomarkers in the sample to a standard, thereby detecting and characterizing alcohol consumption in the subject.
A method of detecting and characterizing alcohol consumption in a subject, comprising:
- assaying a subject sample for a combination of two or more biomarkers of alcohol non-consumption, moderate consumption or high consumption selected from the group consisting of:
- ADIPQ, A2M, C3, CD40, CXCL5, F7, IgE, IGF1, IL2, IL7, CCL3, CCL4, MMP2, KLK3, GOT1, THPO and VEGFA, to determine the level of the two or more biomarkers in the sample;
- and
- comparing the level of the two or more biomarkers in the sample to a standard, thereby detecting and characterizing alcohol consumption in the subject.
A method of detecting alcohol consumption in a subject, comprising:
- assaying a subject sample for at least two of CD40, CXCL5, F7, IgE, IGFI, IL2, IL7, CCL3, CCL4, MMP2, KLK3, GOT1, THPO and VEGFA.
A method of detecting and differentiating moderate alcohol consumption and heavy alcohol consumption in a subject, comprising:
- assaying a subject sample for at least one of ADIPOQ, A2M and C3, to determine the level of ADIPOQ, A2M and/or C3 biomarkers in the sample;
- and
- comparing the level of ADIPOQ, A2M and/or C3 in the sample to a standard, thereby detecting and differentiating moderate alcohol consumption and heavy alcohol consumption in the subject.
A kit for detecting and characterizing alcohol consumption in a subject, comprising:
- a set of binding partners directed to two or more biomarkers selected from:
- A1BG, A2M, ADIPQ, APCS1, APCS2, APOAI, APOC3, C3, C4a, C9, CALCA, CCL3, CCL4, CD40, CLU, CSF2, CXCL5, EGF, F3, F7, FABP3, FN1, GOT1, HRG, IgE, IGF1, IL12p70, IL18, IL2, IL7, ITIH4, KITLG, KLK3, MMP2, RBP4, SAA4, SERPINF1, THPO, VCAM1 and VEGFA, wherein each binding partner is directed to a different biomarker.
Dependencies are inferred from the claim text.