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US 2011/0212444 A1Published application
Use of methylation status of mint loci and tumor related genes as a marker for melanoma and breast cancer
OwnerDave S.B. Hoon, Atsushi Tanemura +1inventors
InventorsDave S.B. Hoon, Atsushi Tanemura, Anneke van Hoesel
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Abstract
The invention relates to a method of detecting melanoma or breast cancer using DNA methylation in MINT17, MINT31, or the promoter region of WIF1, TFPI2, RASSF1A, SOCS1, GATA4, or RARβ2 as a biomarker. Also disclosed are methods of using the biomarker for determining the cancer status and predicting the outcome of the cancer.
Claims10
A method of determining breast cancer status, comprising:
- providing from a subject a sample containing breast cancer cells;
- and
- determining the level of DNA methylation in MINT17, MINT31, or the promoter region of RASSF1A or RARβ2 (retinoic acid receptor beta 2) in the breast cancer cells,
- wherein the level of DNA methylation in MINT17, MINT31, or the promoter region of RASSF1A or RARβ2 in the breast cancer cells, if higher than that in normal cells, indicates that the breast cancer is likely to be an aggressive breast cancer.
1 more element
A method of predicting the outcome of breast cancer, comprising:
- providing from a subject a sample containing breast cancer cells;
- and
- determining the level of DNA methylation in MINT17, MINT31, or the promoter region of RARβ2 in the breast cancer cells,
- wherein a higher level of methylation in MINT17, MINT31, or the promoter region of RARβ2 in the breast cancer cells indicates a less likelihood of overall survival.
1 more element
A method of detecting breast cancer in a subject, comprising:
- providing a DNA sample from a subject;
- and
- determining the level of DNA methylation in MINT17 or MINT31 in the sample,
- wherein the level of DNA methylation in MINT17 or MINT31 in the sample, if higher than that in normal cells, indicates that the subject is suffering from breast cancer.
1 more element
Dependencies are inferred from the claim text.