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US 2011/0212435 A1Published application
Antimicrobial Compounds
AssigneeShaw Intellectual Properties Holding, Inc.
InventorsKevin Rock McClay, Robert Jon Steffan
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Abstract
The compounds disclosed herein are isoxazole derivatives that are useful as antimicrobial compounds, particularly as anti-bacterial compounds. The disclosed methods comprise incubating at least two different substrates in the presence of at least one oxygenase to provide the disclosed compounds, or to prepare and identify compounds that have antimicrobial activity.
Claims10
A method of preparing and identifying a compound that modulates the growth and/or replication of a microorganism, comprising:
- (a) incubating at least a first and second different compound in the presence of at least one oxygenase to provide a test compound;
- (b) contacting the microorganism with the test compound;
- and
- (c) determining a level of growth and/or replication of the microorganism;
- wherein a difference in the level of growth and/or replication of the microorganism as compared to the level in a control identifies the test compound as a compound that modulates the growth and/or replication of the microorganism.
2 more elements
Dependencies are inferred from the claim text.