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US 2011/0212431 A1Published application
Fluidics based pulsatile perfusion preservation device and method
AssigneeBoard of Regents, The University of Texas System
InventorsLeonid Bunegin, Edward F. Gelineau
Life of this patent
Estimating the term…
Abstract
In one embodiment, a preservation apparatus is described that includes a storage compartment. The storage compartment is configured to hold an organ or tissue and a preservation fluid. A cover assembly is configured to engage the storage compartment. The cover assembly includes a support element, wherein the support element together with the storage compartment define a storage chamber. The cover assembly also includes a lid and a gas permeable membrane disposed between the lid and the support element. The gas permeable membrane and the support element together define a perfusion chamber configured to hold preservation fluid and an organ or tissue during use.
Claims155
An apparatus comprising:
- a storage compartment, the storage compartment configured to hold an organ or tissue and a preservation fluid;
- and
- a cover assembly configured to engage the storage compartment, the cover assembly comprising:
- a support element;
- wherein the support element together with the storage compartment define an storage chamber, and wherein at least a portion of the bottom surface of the support element is substantially non-planar;
- a lid;
- and
- a gas permeable membrane disposed between the lid and the support element;
- wherein the gas permeable membrane and the support element define a perfusion chamber configured to hold preservation fluid during use;
- and
- wherein the bottom surface of the support element contacts preservation fluid present in the storage compartment when the cover assembly engages the storage compartment during use.
8 more elements
A system comprising:
- a preservation apparatus, the preservation apparatus comprising:
- a storage compartment, the storage compartment configured to hold an organ or tissue and a preservation fluid;
- and
- a cover assembly configured to engage the storage compartment, the cover assembly comprising:
- a support element;
- wherein the support element together with the storage compartment define a storage chamber, and wherein at least a portion of the bottom surface of the support element is substantially non-planar;
- a lid;
- and
- a gas permeable membrane disposed between the lid and the support element, wherein the gas permeable membrane and the support element define a perfusion chamber configured to hold preservation fluid during use;
- and
- wherein the bottom surface of the support element contacts preservation fluid present in the storage compartment when the cover assembly engages the storage compartment during use;
- an oxygen containing gas supply source;
- and
- a controller coupling the oxygen supply source to the preservation apparatus, wherein the controller is configured to control the flow of oxygen containing gas to the cover assembly such that:
- oxygen containing gas is delivered to the cover assembly when a pressure of the storage compartment is below a predetermined pressure;
- and
- flow of the oxygen containing gas is discontinued, and gasses allowed to vent from the cover assembly, when the pressure of the storage compartment is at or above the predetermined pressure.
14 more elements
A method of preserving an organ or tissue, comprising:
- adding preservation fluid to a preservation apparatus, the preservation apparatus comprising:
- an storage compartment;
- and
- a cover assembly configured to engage the storage compartment, the cover assembly comprising:
- a support element;
- the support element comprising an inlet port and one or more outlet ports, wherein the support element together with the storage compartment define an storage chamber, and wherein at least a portion of the bottom surface of the support element is substantially non-planar;
- a lid;
- and
- a gas permeable membrane disposed between the lid and the support element, wherein the gas permeable membrane and the support element define a perfusion chamber, and wherein the gas permeable membrane and the lid define a pumping chamber;
- wherein the preservation fluid is added to the storage compartment and the perfusion chamber;
- coupling an organ or tissue to the inlet port of the support element;
- placing the organ or tissue into the preservation fluid in the storage compartment by placing the cover assembly onto the storage compartment, wherein the bottom surface of the support element displaces the preservation fluid present in the storage compartment when the cover assembly engages the storage compartment, wherein displacement of the preservation fluid displaces gasses from the storage compartment.
9 more elements
An apparatus comprising:
- a storage compartment, the storage compartment configured to hold an organ or tissue and a preservation fluid;
- and
- a cover assembly configured to engage the storage compartment, the cover assembly comprising:
- a support element;
- wherein the support element together with the storage compartment define an storage chamber;
- a lid;
- a membrane support positioned between the support element and the lid, the membrane support comprising an outer coupling member and one or more membrane support elements extending from the outer coupling member toward an interior region of the membrane support;
- and
- a gas permeable membrane coupled to the membrane support;
- wherein the membrane support positions the gas permeable membrane between the support element and the lid, and wherein the membrane support elements inhibit contact of the membrane with the lid and the support element.
7 more elements
A system comprising:
- a preservation apparatus, the preservation apparatus comprising:
- a storage compartment, the storage compartment configured to hold an organ or tissue and a preservation fluid;
- and
- a cover assembly configured to engage the storage compartment, the cover assembly comprising:
- a support element;
- wherein the support element together with the storage compartment define an storage chamber;
- a lid;
- a membrane support positioned between the support element and the lid, the membrane support comprising an outer coupling member and one or more membrane support elements extending from the outer coupling member toward an interior region of the membrane support;
- and
- a gas permeable membrane coupled to the membrane support;
- wherein the membrane support positions the gas permeable membrane between the support element and the lid, and wherein the membrane support elements inhibit contact of the membrane with the lid and the support element;
- an oxygen containing gas supply source;
- and
- a controller coupling the oxygen containing gas supply source to the preservation apparatus, wherein the controller is configured to control the flow of oxygen containing gas to the cover assembly such that:
- oxygen containing gas is delivered to the cover assembly when a pressure of the storage compartment is below a predetermined pressure;
- and
- flow of oxygen containing gas is discontinued, and gasses allowed to vent from the cover assembly, when the pressure of the storage compartment is at or above the predetermined pressure.
14 more elements
A method of preserving an organ or tissue, comprising:
- adding preservation fluid to a preservation apparatus, the preservation apparatus comprising:
- a storage compartment;
- and
- a cover assembly configured to engage the storage compartment, the cover assembly comprising:
- a support element;
- the support element comprising an inlet port and one or more outlet ports, wherein the support element together with the storage compartment define an storage chamber;
- a lid;
- and
- a membrane support positioned between the support element and the lid, the membrane support comprising an outer coupling member and one or more membrane support elements extending from the outer coupling member toward an interior region of the membrane support;
- and
- a gas permeable membrane coupled to the membrane support, wherein the membrane support and the support element define a perfusion chamber, and wherein the membrane support and the lid define a pumping chamber;
- wherein the preservation fluid is added to the storage compartment and the perfusion chamber;
- coupling an organ or tissue to the inlet port of the support element;
- placing the organ or tissue into the preservation fluid in the storage compartment by placing the cover assembly onto the storage compartment;
- providing oxygen containing gas to the pumping chamber at a pressure sufficient to displace the membrane such that the perfusion cavity is contracted, forcing at least a portion of the preservation fluid in the perfusion cavity through the inlet port into or around the organ or tissue, wherein the membrane support elements inhibit contact of the membrane with the support element.
12 more elements
An apparatus comprising:
- a storage compartment, the storage compartment configured to hold an organ or tissue and a preservation fluid;
- and
- a cover assembly configured to engage the storage compartment, the cover assembly comprising:
- a support element;
- the support element comprising an inlet port configured to engage an organ or tissue, wherein the support element together with the storage compartment define an storage chamber;
- a lid;
- and
- a gas permeable membrane disposed between the lid and the support element;
- wherein the gas permeable membrane and the support element define a perfusion chamber configured to hold preservation fluid during use;
- and
- wherein the inlet port comprises an inlet valve configured to allow flow of fluid from the perfusion chamber to the organ or tissue during use, and wherein the inlet valve is configured to inhibit flow of fluids from the organ or tissue to the perfusion chamber during use.
8 more elements
A system comprising:
- a preservation apparatus, the preservation apparatus comprising:
- a storage compartment, the storage compartment configured to hold an organ or tissue and a preservation fluid;
- and
- a cover assembly configured to engage the storage compartment, the cover assembly comprising:
- a support element;
- the support element comprising an inlet port configured to engage an organ or tissue, wherein the support element together with the storage compartment define an storage chamber;
- a lid;
- and
- a gas permeable membrane disposed between the lid and the support element;
- wherein the gas permeable membrane and the support element define a perfusion chamber configured to hold preservation fluid during use;
- and
- wherein the inlet port comprises an inlet valve configured to allow flow of fluid from the perfusion chamber to the organ or tissue during use, and wherein the inlet valve is configured to inhibit flow of fluids from the organ or tissue to the perfusion chamber during use.
- an oxygen containing gas supply source;
- and
- a controller coupling the oxygen containing gas supply source to the preservation apparatus, wherein the controller is configured to control the flow of oxygen containing gas to the cover assembly such that:
- oxygen containing gas is delivered to the cover assembly when a pressure of the storage compartment is below a predetermined pressure;
- and
- flow of oxygen containing gas is discontinued, and gasses allowed to vent from the cover assembly, when the pressure of the storage compartment is at or above the predetermined pressure.
15 more elements
A method of preserving an organ or tissue, comprising:
- adding preservation fluid to a preservation apparatus, the preservation apparatus comprising:
- a storage compartment, the storage compartment configured to hold an organ or tissue and a preservation fluid;
- and
- a cover assembly configured to engage the storage compartment, the cover assembly comprising:
- a support element;
- the support element comprising an inlet port configured to engage an organ or tissue, wherein the support element together with the storage compartment define an storage chamber;
- a lid;
- and
- a gas permeable membrane disposed between the lid and the support element;
- wherein the gas permeable membrane and the support element define a perfusion chamber configured to hold preservation fluid during use;
- coupling an organ or tissue to the inlet port of the support element;
- placing the organ or tissue into the preservation fluid in the storage compartment by placing the cover assembly onto the storage compartment;
- and
- providing oxygen containing gas to the pumping chamber at a pressure sufficient to displace the membrane such that the perfusion cavity is contracted, forcing at least a portion of the preservation fluid in the perfusion cavity through the inlet port into or around the organ or tissue.
11 more elements
Dependencies are inferred from the claim text.