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AssigneeThe University of Hong Kong
InventorsDaisy Kwok Yan Shum, Mary Sau Man Ip, Chi Hang Chan, Valeria On Yue Leung
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Neutrophil elastase (NE) is a protease secreted by neutrophils during inflammation. Aberrant expression of NE such as in chronic respiratory inflammatory diseases, results in tissue destruction and decline in lung function. Compositions including an NE-targeting agent that targets the pathologic elements of respiratory inflammation are provided. Non-anticoagulant heparin derivatives or fragments are exemplary NE-targeting agents. The compositions preferably include a carrier, such as chitosan, to facilitate delivery of the active agent. Methods of manufacturing non-anticoagulant heparin are also provided. Methods of administering the disclosed compositions to treat respiratory diseases are also disclosed. In preferred methods, an effective amount of the pharmaceutical composition is administered to subject in need thereof to reduce, inhibit, or alleviate one or more symptoms of chronic respiratory inflammation. In the most preferred embodiment, the composition is administered as a dry powder, intranasally or by inhalation.
A pharmaceutical dosage unit for administration to the pulmonary tract or mucosa comprising a pharmaceutically acceptable agent in an amount effective to decrease neutrophil elastase activity in a subject in need thereof, to reduce, prevent, or inhibit one or more biochemical measures or symptoms associated with a respiratory disease or disorder.
Dependencies are inferred from the claim text.