Micro-spherical porous biocompatible scaffolds and methods and apparatus for fabricating same
OwnerDavid Liuinventor
Life of this patent
Estimating the term…
Abstract
Provided herein are bimodal porous polymer microspheres comprising macropores and micropores. Also provided herein are methods and apparatus for fabrication such microspheres. Further provided herein are methods of using bimodal porous polymer microspheres.
Claims136
A method for preparing a bimodal porous polymer particle, said method comprising:
- (a) providing a homogeneous solution comprising a base polymer, a first solvent and a second solvent;
- (b) adding a macropore spacer material to the solution;
- (c) injecting droplets of the solution into a quenching device;
- (d) quenching droplets of the solution to solidify the base polymer into particles having macropores and micropores;
- (e) extracting substantially spherical particles from the quenching device, and optionally sieving the particles;
- and
- (f) optionally washing the macropore spacer material from the particles.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
A bimodal porous particle comprising a base polymer, wherein the particle comprises macropores having a diameter ranging from about 20 to about 500 microns and micropores having a diameter ranging from about 1 to about 70 microns, and wherein the microspheres have a diameter ranging from about 50 to about 1100 microns.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
An apparatus for fabricating bimodal porous polymer particles, comprising:
- (a) a storage vessel;
- (b) a quenching tower;
- (c) an injector comprising a nozzle, wherein the nozzle has a diameter ranging from about 5 to about 1100 microns in diameter;
- and wherein the vessel is connected to the injector;
- and
- (d) one or more microsieves.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.